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Proteintech
RASIP1 Polyclonal Antibody
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产品信息
17971-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RASIP1 Fusion Protein Ag11982 (617-963 aa encoded by BC028614)
偶联物
形式
Liquid
浓度
0.29 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: IGDRQPENH PEGVPEVPLT PEAVSVELRP LMLWMANTTE LLSFVQEKVL EMEKEADQED PQLCNDLELC DEAMALLDEV IMCTFQQSVY YLTKTLYSTL PALLDSNPFT AGAELPGPGA ELGAMPPGLR PTLGVFQAAL ELTSQCELHP DLVSQTFGYL FFFSNASLLN SLMERGQGRP FYQWSRAVQI RTNLDLVLDW LQGAGLGDIA TEFFRKLSMA VNLLCVPRTS LLKASWSSLR TDHPTLTPAQ LHHLLSHYQL GPGRGPPAAW DPPPAEREAV DTGDIFESFS SHPPLILPLG SSRLRLTGPV TDDALHRELR RLRRLLWDLE QQELPANYRH GPPVATSP (617-963 aa encoded by BC028614)
靶标信息
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Rain; Ras-interacting protein 1
基因别名: 1110025D03Rik; 2610025P08Rik; AI853551; RAIN; RASIP1
UniProt ID: (Human) Q5U651, (Mouse) Q3U0S6
Entrez Gene ID: (Human) 54922, (Rat) 292912, (Mouse) 69903
