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Proteintech
RB1 Polyclonal Antibody
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产品信息
25628-1-AP
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RB1 Fusion Protein Ag22578 (373-581 aa encoded by BC039060)
偶联物
形式
Liquid
浓度
0.19 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: TPVRTVMNT IQQLMMILNS ASDQPSENLI SYFNNCTVNP KESILKRVKD IGYIFKEKFA KAVGQGCVEI GSQRYKLGVR LYYRVMESML KSEEERLSIQ NFSKLLNDNI FHMSLLACAL EVVMATYSRS TSQNLDSGTD LSFPWILNVL NLKAFDFYKV IESFIKAEGN LTREMIKHLE RCEHRIMESL AWLSDSPLFD LIKQSKDREG (373-581 aa encoded by BC039060)
靶标信息
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
