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Invitrogen
RBM11 Polyclonal Antibody
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产品信息
PA5-31249
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human RBM11. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.56 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: NT2D1, IMR32, U87-MG.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The RBM11 (RNA Binding Motif Protein 11) gene encodes a protein that belongs to a family of RNA-binding proteins involved in the regulation of alternative splicing, a critical process for generating protein diversity. Located on chromosome 21q22.3, RBM11 contains RNA recognition motifs (RRMs) that facilitate its binding to RNA sequences, influencing splice site selection and exon inclusion or exclusion during pre-mRNA processing. RBM11 is expressed in various tissues, with notable expression in the nervous system, suggesting a role in neural development and function. Dysregulation of RBM11 has been associated with various diseases, including cancer, where it can impact the splicing of key regulatory genes involved in cell proliferation and apoptosis. Understanding the specific RNA targets and splicing events regulated by RBM11 can provide insights into its broader biological roles and its potential as a biomarker or therapeutic target in diseases characterized by aberrant splicing.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: putative RNA-binding protein 11; RNA-binding motif protein 11; Splicing regulator RBM11
基因别名: RBM11
UniProt ID: (Human) P57052
Entrez Gene ID: (Human) 54033
