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Invitrogen
RBPJ Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
图: 1 / 4
RBPJ Antibody (720219) in ICC/IF
For immunofluorescence analysis, HeLa cells were fixed and permeabilized for detection of endogenous CSL/ RBP J using CSL/RBP J Rabbit Polyclonal Antibody (Product # 720219, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of CSL/ RBP J protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). ... View More
产品信息
720219
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Protein corresponding to Human RBPJ (aa 1-200)
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 0.1% BSA, 30% glycerol
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2633205
产品详细信息
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Mouse, Monkey, Bovine, Equine and Pig
靶标信息
CSL plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. The protein is abundantly expressed in heart and skeletal muscle and expression is increased by passive stretch. Mutations in this gene can lead to X-linked deafness.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CBF-1; H-2K binding factor-2; immunoglobulin kappa J region recombination signal binding protein 1; J kappa-recombination signal-binding protein; RBP-J; RBP-J kappa; RBP-JK; rbp-jkappa; Recombining binding protein suppressor of hairless; Renal carcinoma antigen NY-REN-30; suppressor of hairless homolog
基因别名: AOS3; CBF1; csl; IGKJRB; IGKJRB1; KBF2; RBP-J; RBPJ; RBPJK; RBPSUH; SUH
UniProt ID: (Human) Q06330
Entrez Gene ID: (Human) 3516
recombinase activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II repressing transcription factor binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
sequence-specific DNA binding
protein N-terminus binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
somitogenesis
epithelial to mesenchymal transition
blood vessel remodeling
inflammatory response to antigenic stimulus
secondary heart field specification
outflow tract morphogenesis
endocardium morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
cardiac left ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
DNA recombination
transcription initiation from RNA polymerase II promoter
humoral immune response
Notch signaling pathway
positive regulation of transcription of Notch receptor target
negative regulation of cell proliferation
auditory receptor cell fate commitment
epidermal cell fate specification
pituitary gland development
B cell differentiation
keratinocyte differentiation
negative regulation of ossification
positive regulation of BMP signaling pathway
somatic stem cell population maintenance
dorsal aorta morphogenesis
atrioventricular canal development
defense response to bacterium
myeloid dendritic cell differentiation
negative regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of timing of cell differentiation
sebaceous gland development
hair follicle maturation
positive regulation of cardiac muscle cell proliferation
Clara cell differentiation
labyrinthine layer blood vessel development
arterial endothelial cell fate commitment
Notch signaling involved in heart development
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
blood vessel lumenization
interleukin-4 secretion
blood vessel endothelial cell fate specification
positive regulation of ERBB signaling pathway
positive regulation of ephrin receptor signaling pathway
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
positive regulation of cell proliferation involved in heart morphogenesis
