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Immunogen sequence: PSMDCDVSTL VACVVDVEVF TNQEVKE
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Calcipressin-2; Down syndrome candidate region 1-like 1; Down syndrome critical region gene 1-like 1; MCIP2; Myocyte-enriched calcineurin-interacting protein 2; Regulator of calcineurin 2; thyroid hormone-responsive (skin fibroblasts); Thyroid hormone-responsive protein ZAKI-4
基因别名: CSP2; DSCR1L1; MCIP2; RCAN2; RCN2; ZAKI-4; ZAKI4
UniProt ID: (Human) Q14206
Entrez Gene ID: (Human) 10231
分子生物学功能:
intercellular signal molecule
