Immunogen sequence: AEELHYPLGE RRSDYDREAL LGVQEDVDEY VKLGHEEQQK RLQAIIKKID LDSDGFLTES ELSSWIQMSF KHYAMQEAKQ QFVEYDK
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 90%.
The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
蛋白别名: Calcium-binding protein ERC-55; E6-binding protein; E6BP; reticulocalbin 2, EF-hand calcium binding domain (endoplasmic reticulum calcium-binding protein, 55kD); Reticulocalbin-2; taipoxin-associated calcium binding protein 49; Taipoxin-associated calcium-binding protein 49; TCBP-49
基因别名: AA408742; E6BP; ERC-55; ERC55; RCN2; TCBP49