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Invitrogen
RECK Polyclonal Antibody
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RECK Antibody (PA5-117068) in WB
Western blot analysis of RECK in extracts of various cell lines. Samples were incubated with RECK Polyclonal antibody (Product # PA5-117068) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.
产品信息
PA5-117068
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment)
偶联物
形式
Liquid
浓度
1.24 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: 293T, MCF-7, H460, Mouse lung, Mouse kidney
Immunogen sequence: ALECRQACKQ ASSKNDISKV CRKEYENALF SCISRNEMGS VCCSYAGHHT NCREYCQAIF RTDSSPGPSQ IKAVENYCAS ISPQLIHCVN NYTQSYPMRN P
靶标信息
RECK is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hRECK; membrane-anchored glycoprotein (metastasis and invasion); membrane-anchored glycoprotein RECK; mRECK; Reversion-inducing cysteine-rich protein with Kazal motifs; Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK); reversion-inducing-cysteine-rich protein with kazal motifs; suppression of tumorigenicity 15; suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs); suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs); Suppressor of tumorigenicity 15 protein
基因别名: mRECK; RECK; ST15
UniProt ID: (Human) O95980, (Mouse) Q9Z0J1
Entrez Gene ID: (Human) 8434, (Mouse) 53614
blood vessel maturation
embryo implantation
extracellular matrix organization
negative regulation of cell migration
embryonic forelimb morphogenesis
negative regulation of metalloendopeptidase activity
negative regulation of peptidase activity
negative regulation of endopeptidase activity
positive regulation of Notch signaling pathway
