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产品信息
PA5-50988
产品规格
种属反应
Rat,
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from the C-terminal region of human IK.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2636436
产品详细信息
IK Polyclonal Antibody detects endogenous levels of IK protein.
靶标信息
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: arginine/glutamic acid/aspartic acid repeat containing protein; chondrosarcoma-associated protein 2; Cytokine IK; Cytokine IK factor; IK factor; prer protein; Protein Red; Protein RER; RD element
基因别名: CSA2; IK; MuRED; RED; RER
UniProt ID: (Human) Q13123, (Rat) Q66HG8, (Mouse) Q9Z1M8
Entrez Gene ID: (Human) 3550, (Rat) 291659, (Mouse) 24010
