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Proteintech
REST Polyclonal Antibody
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产品信息
22242-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Hamster,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
REST Fusion Protein Ag17707 (748-1097 aa encoded by BC132859)
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: ELSPPMEVV QKEPVKIELS PPIEVVQKEP VQMELSPPMG VVQKEPAQRE PPPPREPPLH MEPISKKPPL RKDKKEKSNM QSERARKEQV LIEVGLVPVK DSWLLKESVS TEDLSPPSPP LPKENLREEA SGDQKLLNTG EGNKEAPLQK VGAEEADESL PGLAANINES THISSSGQNL NTPEGETLNG KHQTDSIVCE MKMDTDQNTR ENLTGINSTV EEPVSPMLPP SAVEEREAVS KTALASPPAT MAANESQEID EDEGIHSHEG SDLSDNMSEG SDDSGLHGAR PVPQESSRKN AKEALAVKAA KGDFVCIFCD RSFRKGKDYS KHLNRHLVNV YYLEEAAQGQ E (748-1097 aa encoded by BC132859)
靶标信息
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Neural-restrictive silencer factor; neuron restrictive silencer factor; neuron-restrictive silencer factor; RE1-silencing transcription factor; RE1-silencing transcription factor variant E1a/E2/E3/E4c; RE1-silencing transcription factor variant E1a/E2/E3/E5; RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i; RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4; RE1-silencing transcription factor variant E1a/E2/E4; RE1-silencing transcription factor variant E1a/E2/E5; RE1-silencing transcription factor variant E1a/E2a/E2k; RE1-silencing transcription factor variant E1a/E2d/E4g; RE1-silencing transcription factor variant E1a/E2e/E4h; RE1-silencing transcription factor variant E1a/E2f/E4e; RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j; RE1-silencing transcription factor variant E1b/E2/E3/E5; RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i; RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4; RE1-silencing transcription factor variant E1b/E2a/E2k; RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4; RE1-silencing transcription factor variant E1b/E2e/E4h; RE1-silencing transcription factor variant E1c/E2/E3/E5; RE1-silencing transcription factor variant E1c/E2a/E2k; RE1-silencing transcription factor variant E1c/E2g/E3/E4; repressor binding to the X2 box; X2 box repressor; zinc finger transcription factor REST protein
基因别名: NRSF; REST; WT6; XBR
UniProt ID: (Human) Q13127, (Rat) O54963
Entrez Gene ID: (Human) 5978, (Rat) 83618
core promoter sequence-specific DNA binding
core promoter binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
histone deacetylase activity
protein binding
transcription factor binding
outward rectifier potassium channel activity
protein complex binding
transcription regulatory region DNA binding
metal ion binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
nucleic acid binding
DNA binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
hematopoietic progenitor cell differentiation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
negative regulation of gene expression
negative regulation of aldosterone biosynthetic process
cellular response to drug
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation by host of viral transcription
negative regulation of neuron differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of calcium ion-dependent exocytosis
negative regulation of insulin secretion
negative regulation of neurogenesis
cardiac muscle cell myoblast differentiation
histone H4 deacetylation
cellular response to electrical stimulus
cellular response to glucocorticoid stimulus
potassium ion transmembrane transport
negative regulation of cortisol biosynthetic process
negative regulation of dense core granule biogenesis
negative regulation of mesenchymal stem cell differentiation
negative regulation of amniotic stem cell differentiation
regulation of transcription from RNA polymerase II promoter
