Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
NeoBiotechnologies
RET Proto-oncogene (Medullary Thyroid Carcinoma Marker) Recombinant Mouse Monoclonal Antibody (r3F8)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 3
RET Proto-oncogene (Medullary Thyroid Carcinoma Marker) Antibody (5979-MSM19-P1ABX) in IHC (P)
Formalin-fixed, paraffin-embedded human colon carcinoma stained with RET Proto-oncogene Recombinant Mouse Monoclonal Antibody (r3F8). Inset: PBS instead of primary antibody; secondary only negative control.
产品信息
5979-MSM19-P1ABX
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
r3F8
抗原
Prokaryotic recombinant fusion protein corresponding to the extreme C-terminal cytoplasmic region of the human ret oncoprotein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Cell membrane, Endosome membrane.
Positive control: Human brain, breast, colon or prostate carcinoma.
靶标信息
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. RET transduce signals for cell growth and differentiation. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described for RET but their biological validity has not been confirmed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Cadherin family member 12; Cadherin family member 12 (CDHF12); Cadherin related family member 16 (CDHR16); cadherin-related family member 16; CUX1/RET fusion; EC 2.7.10.1; ELKS; Hydroxyaryl protein kinase; hydroxyaryl-protein kinase; kinase Ret; Multiple endocrine neoplasia and medullary thyroid carcinoma 1; Oncogene RET; OTTHUMP00000216967; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; rearranged during transfection; receptor tyrosine kinase; RET ELE1; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); RET receptor tyrosine kinase; RET transforming sequence
基因别名: CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET-ELE1; RET51
UniProt ID: (Human) P07949
Entrez Gene ID: (Human) 5979
MAPK cascade
ureteric bud development
neural crest cell migration
embryonic epithelial tube formation
protein phosphorylation
homophilic cell adhesion via plasma membrane adhesion molecules
neuron cell-cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
posterior midgut development
positive regulation of neuron projection development
positive regulation of neuron maturation
peptidyl-tyrosine phosphorylation
regulation of cell adhesion
positive regulation of cell migration
membrane protein proteolysis
positive regulation of cell adhesion mediated by integrin
ureter maturation
response to drug
neuron maturation
positive regulation of GTPase activity
positive regulation of cell size
positive regulation of transcription, DNA-templated
response to pain
enteric nervous system development
regulation of axonogenesis
retina development in camera-type eye
innervation
Peyer's patch morphogenesis
cellular response to retinoic acid
positive regulation of metanephric glomerulus development
lymphocyte migration into lymphoid organs
positive regulation of serine phosphorylation of STAT3 protein
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
