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Invitrogen
RFTN1 Polyclonal Antibody
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产品信息
PA5-83923
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ALHPFVQPTH EREKTPLEHI FRAILIKKTD RSQKTDLHNE GYILELDCCS SLDHPTDQKL IPEFIKKIQE AASQGLKFVG VIPQYHSSV
Highest antigen sequence indentity to the following orthologs: Rat - 78%, Mouse - 78%.
靶标信息
Raftlin, also known as RFTN1 (raftlin, lipid raft linker 1), cell migration-inducing gene 2 protein, PIB10, PIG9 or MIG2, is a 578 amino acid cell membrane protein and lipid anchor that is essential for raft cell assembly and maintenance. A member of the raftlin family, Raftlin modulates B-cell antigen receptor-mediated signaling, TCR signals, and is involved in T cell-mediated immune responses. The gene encoding Raftlin maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cell migration-inducing gene 2 protein; proliferation-inducing protein 10; proliferation-inducing protein 9; Raft-linking protein; Raftlin
基因别名: KIAA0084; MIG2; PIB10; PIG9; RAFTLIN; RFTN1
UniProt ID: (Human) Q14699
Entrez Gene ID: (Human) 23180
membrane raft assembly
T cell antigen processing and presentation
protein transport into membrane raft
interleukin-17 production
dsRNA transport
toll-like receptor 3 signaling pathway
growth
response to exogenous dsRNA
T cell receptor signaling pathway
B cell receptor signaling pathway
protein localization to membrane raft
