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Proteintech
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: DGEEEAGED EADLLDTSDP PGGGESAASL EDLEDEETHS GGEGSSGGAR RRGSGGGSMS KTCTYEGCSE TTSQVAKQRK PWMCKKHRNK MYKDKYKKKK SDQALNCGGT ASTGSAGNVK LEESADNILS IVKQRTGSFG DRPARPTLLE QVLNQKRLSL LRSPEVVQFL QKQQQLLNQQ VLEQRQQQFP GTSM (80-272 aa encoded by BC026088)
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: RFX DNA-binding complex 36 kDa subunit; RFX-AP; RFX-associated protein; unnamed protein product
基因别名: 5730495K23Rik; MHC2D4
UniProt ID: (Human) O00287, (Mouse) Q8VCG9
Entrez Gene ID: (Human) 5994, (Mouse) 170767