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产品信息
PA5-95929
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RGS4 (NP_0056041)
偶联物
形式
Liquid
浓度
0.47 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2807731
产品详细信息
Immunogen sequence: MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR VSQEEVKKWA ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK
Positive Samples: U-251MG, HeLa, A-375, Jurkat, Raji
靶标信息
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC2124; MGC60244; Regulator of G-protein signaling 4; RGP4; RGS4; RP11-430G6.1; schizophrenia disorder 9
基因别名: AA004315; AA597169; ESTM48; ESTM50; RGP4; RGS4; SCZD9
UniProt ID: (Human) P49798, (Mouse) O08899, (Rat) P49799
Entrez Gene ID: (Human) 5999, (Mouse) 19736, (Rat) 29480
inactivation of MAPK activity
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of GTPase activity
negative regulation of G-protein coupled receptor protein signaling pathway
G-protein coupled receptor signaling pathway
negative regulation of signal transduction
termination of G-protein coupled receptor signaling pathway
