Immunogen sequence: ERVALKLDQT FPFSLMRRIS VFKYVSGSSA ERRAAQSRKL NPVPGSYPTQ SCHPHLSPSH PVSQTQHASG QKLA
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 84%.
The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. Little is known about the role of RHBDD2. Its overexpression in breast carcinoma appears to be an indicator of poor prognosis and may play a role in breast cancer progression. The related proteins RHBDD1 and RHBDD3 are both involved in the regulation of apoptosis, suggesting that RHBDD2 may also be involved in the modulation of apoptotic activity.
蛋白别名: H_RG122E10.2a; H_RG122E10.2b; Rhomboid domain-containing protein 2; rhomboid, veinlet-like 7; WUGSC:H_RG122E10.2a; WUGSC:H_RG122E10.2b
基因别名: NPD007; RHBDD2; RHBDL7
UniProt ID: (Human) Q6NTF9
Entrez Gene ID: (Human) 57414
分子生物学功能: primary active transporter