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Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH. Does not regulate lysosomal morphology and distribution (PubMed:14668488). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (PubMed:30398148). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: GAPDH competitor of SIAH protein enhances life; GAPDH's competitor of SIAH1 protein enhances life; GOSPEL; Rab interacting lysosomal protein-like 1; Rab-interacting lysosomal-like protein 1; RILP-like protein 1
基因别名: 2900002H16Rik; 6330559I19Rik; GOSPEL; MNCb-2440; RGD1307973; RILPL1; RLP1
UniProt ID: (Human) Q5EBL4, (Mouse) Q9JJC6, (Rat) D3ZUQ0
Entrez Gene ID: (Human) 353116, (Mouse) 75695, (Rat) 304469