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Invitrogen
RIT2 Polyclonal Antibody
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产品信息
PA5-84888
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MEVENEASCS PGSASGGSRE YKVVM
Highest antigen sequence indentity to the following orthologs: Rat - 84%, Mouse - 88%.
靶标信息
Ras-like without CAAX 2 (RIT2) is a gene located on chromosome 18q12.1, encoding a member of the Ras superfamily of small GTPases. RIT2 is primarily expressed in neuronal tissues, where it plays a crucial role in intracellular signaling pathways that regulate neuronal differentiation, survival, and plasticity. Functionally, RIT2 is involved in neurotrophic factor signaling, contributing to the maintenance and function of the nervous system. This protein interacts with various downstream effectors to influence cellular processes such as growth factor response and neuronal signaling dynamics. Alterations or mutations in RIT2 have been associated with neurological disorders, including Parkinson's disease, implicating its role in neurodegenerative processes. Research into RIT2 aims to elucidate its precise mechanisms in neural signaling and its potential as a therapeutic target for treating neurodegenerative diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GTP-binding protein Rit2; GTP-binding protein Roc2; Ras-like protein expressed in neurons; Ras-like without CAAX 2; Ras-like without CAAX protein 2; Ric-like, expressed in neurons
基因别名: RIBA; RIN; RIT2; ROC2
UniProt ID: (Human) Q99578
Entrez Gene ID: (Human) 6014
MAPK cascade
small GTPase mediated signal transduction
Ras protein signal transduction
chemical synaptic transmission
positive regulation of neuron projection development
regulation of endocytosis
regulation of Cdc42 protein signal transduction
maintenance of protein location in cell
intracellular signal transduction
positive regulation of MAPK cascade
regulation of calcium-mediated signaling
