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Proteintech
RNASEL Polyclonal Antibody
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产品信息
22577-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RNASEL Fusion Protein Ag17409 (392-741 aa encoded by BC115697)
偶联物
形式
Liquid
浓度
0.29 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: KTFCEGSPR AQREVSCLQS SRENSHLVTF YGSESHRGHL FVCVTLCEQT LEACLDVHRG EDVENEEDEF AQNVLSSIFK AVQELHLSCG YTHQDLQPQN ILIDSKKAAH LADFDKSIKW AGDPQEVKRD LEDLGRLVLY VVKKGSISFE ELKAQSNEEV VQLSPDEETK DLIHRLFHPG EHVRDCLSDL LGHPFFWTWE SRYRTLRNVG NESDIKTRKS ESEILRLLQP GPSEHSKSFD KWTTKINECV MKKMNKFYEK RGNFYQNTVG DLLKFIRNLG EHIDEEKHKK MKLKIGDPSL YFQKTFPDLV IYVYTKLQNT EYRKHFPQTH SPNKPQCDGA GGASGLASPG C (392-741 aa encoded by BC115697)
靶标信息
A virally induced endoribonuclease, RNase L is the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L functions in counteracting prostate cancer, via apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNAase; 2-5A-dependent RNase; interferon-induced 2-5A-dependent RNase; Ribonuclease 4; Ribonuclease L; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); RNase L
基因别名: E230029I04Rik; PRCA1; RNASEL; RNS4
UniProt ID: (Human) Q05823, (Mouse) Q05921
Entrez Gene ID: (Human) 6041, (Mouse) 24014
RNA binding
endoribonuclease activity
protein kinase activity
protein binding
ATP binding
rRNA binding
ribonucleoprotein complex binding
metal ion binding
nucleotide binding
nuclease activity
endonuclease activity
ribonuclease activity
bidentate ribonuclease III activity
transferase activity, transferring phosphorus-containing groups
hydrolase activity
rRNA processing
mRNA processing
protein phosphorylation
regulation of mRNA stability
negative regulation of viral genome replication
fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
RNA phosphodiester bond hydrolysis
positive regulation of glucose import in response to insulin stimulus
transmembrane transport
type I interferon signaling pathway
RNA phosphodiester bond hydrolysis, endonucleolytic
