应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
1.25 µg/mL | - |
产品规格 | |
---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide located within the following region: LEEHVQSTNE SLQLVNHEAN SVAVDVIPHV DNPTFEEDET PNQETAVREI |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1.0 mg/mL |
纯化类型 |
Protein A |
保存液 |
PBS, pH 7.4, with 2% sucrose |
内含物 |
0.09% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2817960 |
Sequence homology: Cow: 86%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%
GRAIL is a type I transmembrane protein that localizes to the endocytic pathway and contains a PA (protease associated) domain and a RING-type zinc finger domain. It is a ubiquitin-protein isopeptide ligase (E3) necessary for the induction of CD4(+) T cell anergy in vivo and induced expression of this protein was observed in anergic CD4 (+) T cells, which suggested a role in the induction of anergic phenotype. It is differentially expressed in naturally occurring and peripherally induced CD25 (+) T regulatory cells and the expression is linked to the conversion of these cells to a regulatory phenotype. Expression of GRAIL in retrovirally transduced T cell hybridomas limits activation-induced IL-2 and IL-4 cytokine production. It also functions in the patterning of the dorsal ectoderm and sensitizes ectoderm to respond to neural-inducing signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: E3 ubiquitin-protein ligase RNF128; Gene related to anergy in lymphocytes protein; Goliath-related E3 ubiquitin-protein ligase 1; GRAIL; RING finger protein 128; RING-type E3 ubiquitin transferase RNF128; RP11-150F24.1
基因别名: 1300002C13Rik; AI987883; GRAIL; Greul1; MNCb-3816; RNF128
UniProt ID: (Human) Q8TEB7, (Mouse) Q9D304
Entrez Gene ID: (Human) 79589, (Mouse) 66889