Invitrogen

RNF128 Polyclonal Antibody

Product Image Gallery

RNF128 Antibody in Western Blot (WB) — Western Blot analysis of RNF128 in mouse CD4 T cells using a RNF128 Polyclonal Antibody (Product # PA5-107244) diluted 1:1000. Lane 1: CD4 T cell lysate from WT mice. Lane 2: CD4 T cell lysate from WT mice treated with anti-CD3/CD28. Lane 3: CD4 T cell lysate from WT mice treated with FK506. Lane 4: CD4 T cell lysate from WT mice treated with anti-CD3/CD28 and FK506. Lane 5: CD4 T cell lysate from TRPV1 KO mice. Lane 6: CD4 T cell lysate from TRPV1 KO mice treated with anti-CD3/CD28. Lane 7: CD4 T cell lysate from TRPV1 KO mice treated with FK506. Lane 8: CD4 T cell lysate from TRPV1 KO mice treated with anti-CD3/CD28 and FK506. HRP conjugated secondary antibody diluted 1:10,000. Image courtesy of Christine Quinley, UCSD.

产品信息

PA5-107244

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1.25 µg/mL	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthetic peptide located within the following region: LEEHVQSTNE SLQLVNHEAN SVAVDVIPHV DNPTFEEDET PNQETAVREI
偶联物	Unconjugated
形式	Liquid
浓度	1.0 mg/mL
纯化类型	Protein A
保存液	PBS, pH 7.4, with 2% sucrose
内含物	0.09% sodium azide
保存条件	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID	AB_2817960

产品详细信息

Sequence homology: Cow: 86%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%

靶标信息

GRAIL is a type I transmembrane protein that localizes to the endocytic pathway and contains a PA (protease associated) domain and a RING-type zinc finger domain. It is a ubiquitin-protein isopeptide ligase (E3) necessary for the induction of CD4(+) T cell anergy in vivo and induced expression of this protein was observed in anergic CD4 (+) T cells, which suggested a role in the induction of anergic phenotype. It is differentially expressed in naturally occurring and peripherally induced CD25 (+) T regulatory cells and the expression is linked to the conversion of these cells to a regulatory phenotype. Expression of GRAIL in retrovirally transduced T cell hybridomas limits activation-induced IL-2 and IL-4 cytokine production. It also functions in the patterning of the dorsal ectoderm and sensitizes ectoderm to respond to neural-inducing signals.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: E3 ubiquitin-protein ligase RNF128; Gene related to anergy in lymphocytes protein; Goliath-related E3 ubiquitin-protein ligase 1; GRAIL; RING finger protein 128; RING-type E3 ubiquitin transferase RNF128; RP11-150F24.1

基因别名: 1300002C13Rik; AI987883; GRAIL; Greul1; MNCb-3816; RNF128

UniProt ID: (Human) Q8TEB7, (Mouse) Q9D304

Entrez Gene ID: (Human) 79589, (Mouse) 66889

功能

regulation of protein stability negative regulation of cytokine biosynthetic process protein ubiquitination involved in ubiquitin-dependent protein catabolic process protein localization to lysosome positive regulation of protein catabolic process in the vacuole protein ubiquitination

参与通路