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Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: E3 ubiquitin-protein ligase Praja-2; E3 ubiquitin-protein ligase Praja2; neurodegeneration associated protein 1; praja 2, RING-H2 motif containing; praja ring finger 2, E3 ubiquitin protein ligase; praja-2; Praja2; protein carrying the RING-H2 sequence motif; RING finger protein 131; RING-type E3 ubiquitin transferase Praja-2
基因别名: AI447901; AL022700; KIAA0438; mKIAA0438; Neurodap1; PJA2; praja2; RNF131
UniProt ID: (Human) O43164, (Mouse) Q80U04, (Rat) Q63364
Entrez Gene ID: (Human) 9867, (Mouse) 224938, (Rat) 192256