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Immunogen sequence: AQPESIRSDL ESSDAQSDDV PDITSDECGS PRSHTAACPS TPRAQGAPSP SAHMNLSALA EGQTVLKPEG GEA
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 84%.
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: E3 ubiquitin-protein ligase RNF19B; IBR domain-containing protein 3; Natural killer lytic-associated molecule; RING finger protein 19B
基因别名: IBRDC3; NKLAM; RNF19B
UniProt ID: (Human) Q6ZMZ0
Entrez Gene ID: (Human) 127544
分子生物学功能:
ubiquitin-protein ligase