Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
5 µg/mL | 查看1篇已发表文章 1篇已发表文章 |
流式细胞分析 (Flow) |
0.25-0.5 µg per million cells | - |
产品规格 | |
---|---|
种属反应 |
Human, Mouse, Rat |
已发表种属 |
Mouse |
宿主/亚型 |
Mouse / IgG1, kappa |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
4G419 |
抗原 |
Synthetic peptide (2 DRAPQRQHRASRELLAAKKTHTSQIE 27) of Retinoid-Related Orphan Receptor Gamma protein. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1.0 mg/mL |
纯化类型 |
Protein A/G |
保存液 |
PBS |
内含物 |
0.05% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2537745 |
ROR gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. Reports suggest thatROR gammais a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR gamma shares 50 to 51% sequence identity with RORA and RORB and is 88% identical to mouse ROR gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan nuclear receptor variant 2; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; Retinoid-related orphan receptor-gamma; Thymus orphan receptor; TOR
基因别名: IMD42; NR1F3; RORC; RORG; RORgamma; RZR-GAMMA; RZRG; Thor; TOR
UniProt ID: (Human) P51449, (Mouse) P51450
Entrez Gene ID: (Human) 6097, (Rat) 368158, (Mouse) 19885
分子生物学功能:
C4 zinc finger nuclear receptor