Product References
RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation.
Nature communications
Singh AK,Kumar R,Yin J,Brooks Ii JF,Kathania M,Mukherjee S,Kumar J,Conlon KP,Basrur V,Chen Z,Han X,Hooper LV,Burstein E,Venuprasad K
14-6988-82 was used in Proximity Ligation Assay (PLA) to identify a mechanism that drives the pathogenic function of Th17 cells, which could provide a platform for advanced therapeutic strategies to dampen Th17-mediated inflammatory diseases.
Thu Aug 17 00:00:00 UTC 2023
RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation.
Nature communications
Singh AK,Kumar R,Yin J,Brooks Ii JF,Kathania M,Mukherjee S,Kumar J,Conlon KP,Basrur V,Chen Z,Han X,Hooper LV,Burstein E,Venuprasad K
14-6988-82 was used in Proximity Ligation Assay (PLA) to identify a mechanism that drives the pathogenic function of Th17 cells, which could provide a platform for advanced therapeutic strategies to dampen Th17-mediated inflammatory diseases.
Thu Aug 17 00:00:00 UTC 2023
Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming.
Nature communications
Aso K,Kono M,Kanda M,Kudo Y,Sakiyama K,Hisada R,Karino K,Ueda Y,Nakazawa D,Fujieda Y,Kato M,Amengual O,Atsumi T
14-6988-82 was used in Immunoprecipitation, Western Blot, ChIP Assay to indicate that itaconate is a crucial metabolic regulator for Th17/Treg cell balance and could be a potential therapeutic agent for autoimmune diseases.
Mon Feb 27 00:00:00 UTC 2023
Deciphering the pharmacological mechanisms of Fraxini Cortex for ulcerative colitis treatment based on network pharmacology and in vivo studies.
BMC complementary medicine and therapies
Wang T,Su X,Peng J,Tan X,Yang G,Zhang T,Chen F,Wang C,Ma K
14-6988-82 was used in Western Blotting to show that FC alleviated DSS-induced colitis symptoms, reduced inflammatory cytokines release, and suppressed the expression levels of IL1β, COX2, MMP3, IL-17 and RORγt in colon tissues.
Tue May 09 00:00:00 UTC 2023
CYP11A1‑derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomas.
International journal of oncology
Slominski AT,Brożyna AA,Kim TK,Elsayed MM,Janjetovic Z,Qayyum S,Slominski RM,Oak ASW,Li C,Podgorska E,Li W,Jetten AM,Tuckey RC,Tang EKY,Elmets C,Athar M
14-6988-82 was used in Western Blotting to suggest that they might provide targets for endogenously produced or exogenously applied vitamin D hydroxyderivatives and provide excellent candidates for anti‚cancer therapy.
Mon Aug 01 00:00:00 UTC 2022
Iron controls T helper cell pathogenicity by promoting glucose metabolism in autoimmune myopathy.
Clinical and translational medicine
Lai Y,Zhao S,Chen B,Huang Y,Guo C,Li M,Ye B,Wang S,Zhang H,Yang N
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Western Blot
Mon Aug 01 00:00:00 UTC 2022
Desmosterol: A natural product derived from macroalgae modulates inflammatory response and oxidative stress pathways in intestinal epithelial cells.
Frontiers in immunology
Qu H,Zong Q,Hu P,Li Z,Wang H,Wu S,Liu HY,Bao W,Cai D
14-6988-82 was used in Western Blotting to underscore the vital physiological actions of DES in inflammatory and oxidative processes possibly via RORγ, and may be helpful in anti-oxidation treatment and immunotherapy in the future.
Tue Jan 24 00:00:00 UTC 2023
Targeted Assessment of Mucosal Immune Gene Expression Predicts Clinical Outcomes in Children with Ulcerative Colitis.
Journal of Crohn's & colitis
Clarkston K,Karns R,Jegga AG,Sharma M,Fox S,Ojo BA,Minar P,Walters TD,Griffiths AM,Mack DR,Boyle B,LeLeiko NS,Markowitz J,Rosh JR,Patel AS,Shah S,Baldassano RN,Pfefferkorn M,Sauer C,Kugathasan S,Haberman Y,Hyams JS,Denson LA,Rosen MJ
14-6988-82 was used in Immunohistochemistry (Paraffin) to reveal IL13RA2 and RORC co-expressed genes were localized to inflammatory fibroblasts and undifferentiated epithelial cells, respectively, which was supported by protein immunostaining.
Wed Nov 23 00:00:00 UTC 2022
Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function.
Nature communications
Cheng HW,Mörbe U,Lütge M,Engetschwiler C,Onder L,Novkovic M,Gil-Cruz C,Perez-Shibayama C,Hehlgans T,Scandella E,Ludewig B
14-6988-82 was used in Immunoprecipitation, Western Blot, Immunohistochemistry to indicate critical fibroblastic niches within the intestinal lamina propria that control ILC homeostasis and functionality and thereby secure protective gut immunity.
Tue Apr 19 00:00:00 UTC 2022
Sodium butyrate alleviates deoxynivalenol-induced hepatic cholesterol metabolic dysfunction via RORγ-mediated histone acetylation modification in weaning piglets.
Journal of animal science and biotechnology
Zong Q,Qu H,Zhao Y,Liu H,Wu S,Wang S,Bao W,Cai D
14-6988-82 was used in Western Blot to demonstrate the utility of the natural product NaBu as a potential anti-mycotoxin nutritional strategy for regulating cholesterol metabolism via RORγ-mediated histone acetylation modification.
Fri Dec 23 00:00:00 UTC 2022
Group 3 innate lymphoid cell pyroptosis represents a host defence mechanism against Salmonella infection.
Nature microbiology
Xiong L,Wang S,Dean JW,Oliff KN,Jobin C,Curtiss R,Zhou L
14-6988-82 was used in Immunohistochemistry to suggest a key host defence mechanism against S. Typhimurium infection via induction of ILC3 death to limit intracellular bacteria and reduce IL-22 production.
Fri Jul 01 00:00:00 UTC 2022
Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade.
Cancer discovery
Lander VE,Belle JI,Kingston NL,Herndon JM,Hogg GD,Liu X,Kang LI,Knolhoff BL,Bogner SJ,Baer JM,Zuo C,Borcherding NC,Lander DP,Mpoy C,Scott J,Zahner M,Rogers BE,Schwarz JK,Kim H,DeNardo DG
14-6988-82 was used in Mass Spectrometry to show that FAK inhibition allows RT to prime tumor immunity and unlock responsiveness to checkpoint immunotherapy.
Fri Dec 02 00:00:00 UTC 2022
Deubiquitinase USP29 correlates RORγt expression and its association with thymoma myasthenia gravis.
American journal of translational research
Xia D,Pan L,Fu X,Meng Y,Li M,Wang W,Wang Z
14-6988-82 was used in Western Blotting to suggest that USP29 might take part in the regulation of RORγt expression and Th17 cell generation and constitute an innovative regulatory function for USP29 in autoimmune disease.
Thu Jan 12 00:00:00 UTC 2023
Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation.
Cell reports
Kathania M,Kumar R,Lenou ET,Basrur V,Theiss AL,Chernoff J,Venuprasad K
14-6988-82 was used in Immunoprecipitation to uncover a mechanism by which the activity of RORγt is regulated that can be exploited therapeutically.
Tue Sep 13 00:00:00 UTC 2022
STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program.
Cell reports
Damasceno LEA,Cebinelli GCM,Fernandes MF,Nascimento DC,Públio GA,Vinolo MAR,Oliveira SC,Sparwasser T,Cunha TM,Cunha FQ,Alves-Filho JC
14-6988-82 was used in ChIP Assay, Immunoprecipitation, Western Blot to describe an intrinsic role of STING in limiting the TH17 cell pathogenic program and reveal a regulatory function of STING in the TH17 cell activation program, proposing it as a valuable target to limit TH17-cell-mediated inflammation.
Tue May 24 00:00:00 UTC 2022
CD2+ T-helper 17-like cells differentiated from a CD133+ subpopulation of non-small cell lung carcinoma cells promote the growth of lung carcinoma.
Annals of translational medicine
Jia M,Jia X,Zhang D,Liu W,Yi S,Li Z,Cong B,Ma C,Li S,Zhang J
14-6988-82 was used in Western Blot to test the potential of cancer stem cells to differentiate into neoplastic immune cells and evaluate the capacity of immune-like cells to participate in the process of tumorigenesis.
Thu Apr 01 00:00:00 UTC 2021
AMPK induces regulatory innate lymphoid cells after traumatic brain injury.
JCI insight
Baban B,Braun M,Khodadadi H,Ward A,Alverson K,Malik A,Nguyen K,Nazarian S,Hess DC,Forseen S,Post AF,Vale FL,Vender JR,Hoda MN,Akbari O,Vaibhav K,Dhandapani KM
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Mon Jan 11 00:00:00 UTC 2021
ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.
Cell reports
Teng F,Tachó-Piñot R,Sung B,Farber DL,Worgall S,Hammad H,Lambrecht BN,Hepworth MR,Sonnenberg GF
14-6988-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry to demonstrate a critical role for antigen-presenting ILC3s in orchestrating immune tolerance in the airway by restricting pro-inflammatory T cell responses to both allergens and microbes.
Tue Nov 23 00:00:00 UTC 2021
Microbial exposure during early human development primes fetal immune cells.
Cell
Mishra A,Lai GC,Yao LJ,Aung TT,Shental N,Rotter-Maskowitz A,Shepherdson E,Singh GSN,Pai R,Shanti A,Wong RMM,Lee A,Khyriem C,Dutertre CA,Chakarov S,Srinivasan KG,Shadan NB,Zhang XM,Khalilnezhad S,Cottier F,Tan ASM,Low G,Chen P,Fan Y,Hor PX,Lee AKM,Choolani M,Vermijlen D,Sharma A,Fuks G,Straussman R,Pavelka N,Malleret B,McGovern N,Albani S,Chan JKY,Ginhoux F
14-6988-82 was used in Immunohistochemistry, Immunoprecipitation, Western Blot to indicate selective presence of live microbes in fetal organs during the 2nd trimester of gestation and have broader implications toward the establishment of immune competency and priming before birth.
Thu Jun 24 00:00:00 UTC 2021
Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.
Cell reports
Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR
14-6988-82 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.
Tue Aug 24 00:00:00 UTC 2021
Repurposing the anthelmintic praziquantel to treat psoriasis.
British journal of pharmacology
Hao L,Mao Y,Park J,Bae EJ,Park BH
14-6988-82 was used in Western Blotting to provide the first preclinical evidence that praziquantel may effectively treat psoriasis, and suggest that praziquantel alleviates symptoms in mice by inhibiting STAT3 phosphorylation, thereby suppressing Th17 immune responses.
Wed Dec 01 00:00:00 UTC 2021
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.
Cell research
Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z
14-6988-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.
Wed Jul 01 00:00:00 UTC 2020
Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.
The Journal of clinical investigation
Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Wed Apr 01 00:00:00 UTC 2020
The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens.
The Journal of experimental medicine
Kang L,Zhang X,Ji L,Kou T,Smith SM,Zhao B,Guo X,Pineda-Torra I,Wu L,Hu X
14-6988-82 was used in Flow Cytometry to demonstrate that colonic macrophage-intrinsic RBP-J dynamically orchestrates intestinal immunity against pathogen infections by interfacing with key immune cells of T and innate lymphoid cell lineages.
Mon Apr 06 00:00:00 UTC 2020
JQ1, a bromodomain inhibitor, suppresses Th17 effectors by blocking p300-mediated acetylation of RORγt.
British journal of pharmacology
Wang X,Yang Y,Ren D,Xia Y,He W,Wu Q,Zhang J,Liu M,Du Y,Ren C,Li B,Shen J,Zhang Y
14-6988-82 was used in Western Blot to investigate if JQ1 suppresses the response of Th17 cells by impairing p300-mediated acetylation of RORγt.
Wed Jul 01 00:00:00 UTC 2020
BML-111 treatment prevents cardiac apoptosis and oxidative stress in a mouse model of autoimmune myocarditis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jaén RI,Fernández-Velasco M,Terrón V,Sánchez-García S,Zaragoza C,Canales-Bueno N,Val-Blasco A,Vallejo-Cremades MT,Boscá L,Prieto P
14-6988-82 was used in Immunohistochemistry to indicate that treatment with the lipoxin derivative BML-111 effectively alleviates EAM outcome and prevents cardiac dysfunction, thus, underscoring the therapeutic potential of lipoxins and their derivatives to treat myocarditis and other inflammatory cardiovascular diseases.
Sat Aug 01 00:00:00 UTC 2020
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.
Investigative ophthalmology & visual science
Han F,Guo H,Wang L,Zhang Y,Sun L,Dai C,Wu X
14-6988-82 was used in Western Blot to investigate the role of thymic stromal lymphopoietin secreted by Aspergillus fumigatus–stimulated dendritic cells during the T helper 17 immune response.
Tue Dec 01 00:00:00 UTC 2020
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.
Investigative ophthalmology & visual science
Han F,Guo H,Wang L,Zhang Y,Sun L,Dai C,Wu X
14-6988-82 was used in Western Blot to investigate the role of thymic stromal lymphopoietin secreted by Aspergillus fumigatus–stimulated dendritic cells during the T helper 17 immune response.
Tue Dec 01 00:00:00 UTC 2020
Abnormal Eating Patterns Cause Circadian Disruption and Promote Alcohol-Associated Colon Carcinogenesis.
Cellular and molecular gastroenterology and hepatology
Bishehsari F,Engen PA,Voigt RM,Swanson G,Shaikh M,Wilber S,Naqib A,Green SJ,Shetuni B,Forsyth CB,Saadalla A,Osman A,Hamaker BR,Keshavarzian A,Khazaie K
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Immunohistochemistry
Wed May 05 00:00:00 UTC 2021
Intestinal vitamin D receptor knockout protects from oxazolone-induced colitis.
Cell death & disease
Shi Y,Liu Z,Cui X,Zhao Q,Liu T
14-6988 was used in Western Blotting to identify that intestinal vitamin D receptor knockout protected against oxazolone-induced colitis in mice by blocking Th2 cell response and reducing the function of intestinal invariant natural killer T cells.
Mon Jun 15 00:00:00 UTC 2020
Ahr-Foxp3-RORγt axis controls gut homing of CD4+ T cells by regulating GPR15.
Science immunology
Xiong L,Dean JW,Fu Z,Oliff KN,Bostick JW,Ye J,Chen ZE,Mühlbauer M,Zhou L
14-6988 was used in Chromatin immunoprecipitation to demonstrate a key role for Ahr in regulating Treg intestinal homing under the steady state and during inflammation and the importance of Ahr-RORγt-Foxp3 axis in regulating gut homing receptor GPR15 expression by lymphocytes.
Fri Jun 12 00:00:00 UTC 2020
Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity.
Immunity
Chun E,Lavoie S,Fonseca-Pereira D,Bae S,Michaud M,Hoveyda HR,Fraser GL,Gallini Comeau CA,Glickman JN,Fuller MH,Layden BT,Garrett WS
14-6988-82 was used in Immunohistochemistry to demonstrate group 3 innate lymphoid cells are regulated by the metabolite-sensing receptor Ffar2.
Tue Nov 19 00:00:00 UTC 2019
Establishment of Chronic Typhoid Infection in a Mouse Carriage Model Involves a Type 2 Immune Shift and T and B Cell Recruitment to the Gallbladder.
mBio
González JF,Kurtz J,Bauer DL,Hitt R,Fitch J,Wetzel A,La Perle K,White P,McLachlan J,Gunn JS
14-6988 was used in Flow cytometry/Cell sorting to analyze the transcriptional profile of the gallbladder in a mouse model of chronic carriage.
Tue Oct 01 00:00:00 UTC 2019
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.
Immunity
Emgård J,Kammoun H,García-Cassani B,Chesné J,Parigi SM,Jacob JM,Cheng HW,Evren E,Das S,Czarnewski P,Sleiers N,Melo-Gonzalez F,Kvedaraite E,Svensson M,Scandella E,Hepworth MR,Huber S,Ludewig B,Peduto L,Villablanca EJ,Veiga-Fernandes H,Pereira JP,Flavell RA,Willinger T
14-6988 was used in Immunohistochemistry-immunofluorescence to show that GPR183 promotes lymphoid organ development and indicate that oxysterol-GPR183-dependent positioning within tissues controls ILC3 activity and intestinal homeostasis.
Tue Jan 16 00:00:00 UTC 2018
Trim33 mediates the proinflammatory function of Th17 cells.
The Journal of experimental medicine
Tanaka S,Jiang Y,Martinez GJ,Tanaka K,Yan X,Kurosaki T,Kaartinen V,Feng XH,Tian Q,Wang X,Dong C
14-6988 was used in Western Blotting to study the mechanism by which transforming growth factor-Β regulates reciprocal regulatory T cell and T helper 17 differentiation.
Mon Jul 02 00:00:00 UTC 2018
BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation.
The Journal of experimental medicine
Deason K,Troutman TD,Jain A,Challa DK,Mandraju R,Brewer T,Ward ES,Pasare C
14-6988 was used in Flow Cytometry to study the role of B cell adapter for phosphoinositide 3-kinase downstream of both interleukin-1 and IL-18 receptors in the regulation of T helper17 and Th1 cell differentiation.
Mon Sep 03 00:00:00 UTC 2018
Human CD40 ligand-expressing type 3 innate lymphoid cells induce IL-10-producing immature transitional regulatory B cells.
The Journal of allergy and clinical immunology
Komlósi ZI,Kovács N,van de Veen W,Kirsch AI,Fahrner HB,Wawrzyniak M,Rebane A,Stanic B,Palomares O,Rückert B,Menz G,Akdis M,Losonczy G,Akdis CA
14-6988 was used in Flow cytometry/Cell sorting to investigate the ILC3-B-cell interaction that probably takes place in human tonsils.
Sun Jul 01 00:00:00 UTC 2018
Fisetin inhibits pristine-induced systemic lupus erythematosus in a murine model through CXCLs regulation.
International journal of molecular medicine
Xu SP,Li YS
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Sat Dec 01 00:00:00 UTC 2018
High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice.
Scientific reports
Dar HY,Singh A,Shukla P,Anupam R,Mondal RK,Mishra PK,Srivastava RK
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Tue Feb 06 00:00:00 UTC 2018
Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28.
Nature communications
Jiang Y,Liu Y,Lu H,Sun SC,Jin W,Wang X,Dong C
14-6988 was used in Western Blotting to uncover the mediator of epigenetic activation during Th17 differentiation.
Thu Apr 12 00:00:00 UTC 2018
Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer.
Journal for immunotherapy of cancer
Pennock ND,Martinson HA,Guo Q,Betts CB,Jindal S,Tsujikawa T,Coussens LM,Borges VF,Schedin P
14-6988 was used in Immunohistochemistry on paraffin embedded tissues to implicate beneficial prophylactic use of ibuprofen during the pro-tumorigenic window of mammary gland involution.
Mon Oct 01 00:00:00 UTC 2018
The role of RORα in salivary gland lesions in patients with primary Sjögren's syndrome.
Arthritis research & therapy
Weng X,Liu Y,Cui S,Cheng B
14-6988-82 was used in Western Blot to reveal the importance of RORα in controlling pathologic lymphocytic infiltration of the salivary glands and suggest that RORα may be a druggable target in treating pSS.
Thu Sep 06 00:00:00 UTC 2018
Inflammation-induced Id2 promotes plasticity in regulatory T cells.
Nature communications
Hwang SM,Sharma G,Verma R,Byun S,Rudra D,Im SH
14-6988 was used in Flow cytometry/Cell sorting to show that pro-inflammatory cytokines enhance the expression of transcription regulator Id2, which mediates cellular plasticity of Treg into ex-Foxp3 TH17 cells.
Fri Nov 09 00:00:00 UTC 2018
Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers.
Journal of leukocyte biology
de Bourayne M,Gallais Y,El Ali Z,Rousseau P,Damiens MH,Cochet C,Filhol O,Chollet-Martin S,Pallardy M,Kerdine-Römer S
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Wed Mar 01 00:00:00 UTC 2017
PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Webb LM,Amici SA,Jablonski KA,Savardekar H,Panfil AR,Li L,Zhou W,Peine K,Karkhanis V,Bachelder EM,Ainslie KM,Green PL,Li C,Baiocchi RA,Guerau-de-Arellano M
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Wed Feb 15 00:00:00 UTC 2017
Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10.
Journal of immunology (Baltimore, Md. : 1950)
Zanin-Zhorov A,Weiss JM,Trzeciak A,Chen W,Zhang J,Nyuydzefe MS,Arencibia C,Polimera S,Schueller O,Fuentes-Duculan J,Bonifacio KM,Kunjravia N,Cueto I,Soung J,Fleischmann RM,Kivitz A,Lebwohl M,Nunez M,Woodson J,Smith SL,West RF,Berger M,Krueger JG,Ryan JL,Waksal SD
14698882 was used in immunohistochemistry to find that oral administration of a selective Rho-associated kinase 2 inhibitor, KD025, reduces psoriasis area in 46% of patients with psoriasis vulgaris
Mon May 15 00:00:00 UTC 2017
Characterisation of innate lymphoid cell populations at different sites in mice with defective T cell immunity.
Wellcome open research
Dutton EE,Camelo A,Sleeman M,Herbst R,Carlesso G,Belz GT,Withers DR
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Sat Jan 09 00:00:00 UTC 2021
CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.
Nature communications
Barthels C,Ogrinc A,Steyer V,Meier S,Simon F,Wimmer M,Blutke A,Straub T,Zimber-Strobl U,Lutgens E,Marconi P,Ohnmacht C,Garzetti D,Stecher B,Brocker T
14698882 was used in flow cytometry to report a CD40-dependent mechanism capable of abrogating inducible T regulatory cell induction by dendritic cells
Thu Mar 09 00:00:00 UTC 2017
WASH maintains NKp46+ ILC3 cells by promoting AHR expression.
Nature communications
Xia P,Liu J,Wang S,Ye B,Du Y,Xiong Z,Han ZG,Tong L,Fan Z
14-6988 was used in Flow cytometry/Cell sorting to study how WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.
Wed Jun 07 00:00:00 UTC 2017
JunB is essential for IL-23-dependent pathogenicity of Th17 cells.
Nature communications
Hasan Z,Koizumi SI,Sasaki D,Yamada H,Arakaki N,Fujihara Y,Okitsu S,Shirahata H,Ishikawa H
14-6988 was used in Western Blotting to study the role of the AP-1 transcription factor in the induction of pathogenicity of TH17 cells.
Tue May 30 00:00:00 UTC 2017
High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice.
Oncotarget
Wei Y,Lu C,Chen J,Cui G,Wang L,Yu T,Yang Y,Wu W,Ding Y,Li L,Uede T,Chen Z,Diao H
14698882 was used in flow cytometry to determine the effect of a high salt diet on intestinal immunity and the risk of inflammatory bowel disease
Tue Jan 03 00:00:00 UTC 2017
ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer.
Nature medicine
Wang J,Zou JX,Xue X,Cai D,Zhang Y,Duan Z,Xiang Q,Yang JC,Louie MC,Borowsky AD,Gao AC,Evans CP,Lam KS,Xu J,Kung HJ,Evans RM,Xu Y,Chen HW
14-6988 was used in Immunohistochemistry to study the role of retinoic acid receptor-related orphan receptor γ in castration-resistant prostate cancer, and it's potential as a therapeutic target.
Sun May 01 00:00:00 UTC 2016
An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.
Nature medicine
Massoud AH,Charbonnier LM,Lopez D,Pellegrini M,Phipatanakul W,Chatila TA
14-6988 was used in Flow cytometry/Cell sorting to identify a previously unknown mechanism for the development of TH17 cell inflammation in genetically prone individuals.
Thu Sep 01 00:00:00 UTC 2016
Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence.
Nature
Ibiza S,García-Cassani B,Ribeiro H,Carvalho T,Almeida L,Marques R,Misic AM,Bartow-McKenney C,Larson DM,Pavan WJ,Eberl G,Grice EA,Veiga-Fernandes H
14698882 was used in flow cytometry to explain how glial cells impact ILC3-derived IL-22
Thu Jul 21 00:00:00 UTC 2016
Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment.
Nature immunology
Zhong C,Cui K,Wilhelm C,Hu G,Mao K,Belkaid Y,Zhao K,Zhu J
14698882 was used in immunohistochemistry - frozen section to explore the contributions of GATA3 to the group 3 innate lymphoid cells
Mon Feb 01 00:00:00 UTC 2016
Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity.
The Journal of experimental medicine
Kishi Y,Kondo T,Xiao S,Yosef N,Gaublomme J,Wu C,Wang C,Chihara N,Regev A,Joller N,Kuchroo VK
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in ChIP assay
Mon Oct 17 00:00:00 UTC 2016
Development of Th17-Associated Interstitial Kidney Inflammation in Lupus-Prone Mice Lacking the Gene Encoding STAT-1.
Arthritis & rheumatology (Hoboken, N.J.)
Yiu G,Rasmussen TK,Ajami B,Haddon DJ,Chu AD,Tangsombatvisit S,Haynes WA,Diep V,Steinman L,Faix J,Utz PJ
14-6988 was used in Immunofluorescence on frozen tissues to investigate the roles of the type I and type II IFN signaling components in systemic Lupus Erythematosus, showing the development of Th17-associated interstitial kidney inflammation in mice lacking STAT-1.
Sun May 01 00:00:00 UTC 2016
Heat-killed Staphylococcus aureus reduces atherosclerosis by inducing anti-inflammatory macrophages.
Journal of internal medicine
Frodermann V,van Duijn J,van Puijvelde GH,van Santbrink PJ,Lagraauw HM,de Vries MR,Quax PH,Bot I,Foks AC,de Jager SC,Kuiper J
14698882 was used in flow cytometry to test whether heat-killed Staphyloccocus aureus inhibits the development of atherosclerosis
Wed Jun 01 00:00:00 UTC 2016
IL-1β, But Not Programed Death-1 and Programed Death Ligand Pathway, Is Critical for the Human Th17 Response to Mycobacterium tuberculosis.
Frontiers in immunology
Stephen-Victor E,Sharma VK,Das M,Karnam A,Saha C,Lecerf M,Galeotti C,Kaveri SV,Bayry J
14-6988 was used in Flow cytometry/Cell sorting to investigate the role of PD pathway in regulating Th17 response to M. tuberculosis, showing that IL-1β, but not that PD-1 pathway, is critical for response.
Wed Nov 20 00:00:00 UTC 2019
B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse.
European journal of immunology
Carrascal J,Carrillo J,Arpa B,Egia-Mendikute L,Rosell-Mases E,Pujol-Autonell I,Planas R,Mora C,Mauricio D,Ampudia RM,Vives-Pi M,Verdaguer J
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Tue Mar 01 00:00:00 UTC 2016
p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
European journal of immunology
Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Fri Jan 01 00:00:00 UTC 2016
Human mast cells capture, store, and release bioactive, exogenous IL-17A.
Journal of leukocyte biology
Noordenbos T,Blijdorp I,Chen S,Stap J,Mul E,Cañete JD,Lubberts E,Yeremenko N,Baeten D
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Western Blot
Thu Sep 01 00:00:00 UTC 2016
Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance.
Experimental and therapeutic medicine
Zhao J,Ma J,Zhang X,Li Q,Yang X
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Wed Jun 01 00:00:00 UTC 2016
Retinoic Acid Differentially Regulates the Migration of Innate Lymphoid Cell Subsets to the Gut.
Immunity
Kim MH,Taparowsky EJ,Kim CH
14698882 was used in flow cytometry to discuss tissue tropisms of innate lymphoid cells
Tue Jul 21 00:00:00 UTC 2015
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
Immunity
Mackay LK,Wynne-Jones E,Freestone D,Pellicci DG,Mielke LA,Newman DM,Braun A,Masson F,Kallies A,Belz GT,Carbone FR
14-6988 was used in Flow cytometry/Cell sorting to indicate that the T-box TFs control the two cytokines, TGF-β and IL-15, which are pivotal for CD8(+)CD103(+) Trm cell development and survival.
Tue Dec 15 00:00:00 UTC 2015
Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway.
Mucosal immunology
Park J,Kim M,Kang SG,Jannasch AH,Cooper B,Patterson J,Kim CH
14-6988 was used in Flow cytometry/Cell sorting to show that short-chain fatty acids promote T-cell differentiation to promote either immunity or immune tolerance.
Thu Jan 01 00:00:00 UTC 2015
Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection.
Mucosal immunology
Jiang TT,Chaturvedi V,Ertelt JM,Xin L,Clark DR,Kinder JM,Way SS
14-6988 was used in Flow cytometry/Cell sorting to study susceptibility against Candida albicans fungal infectiong following eradication of commensal enteric bacteria, showing loss of commensal bacteria enhances antifungal immunity through robust systemic expansion of Ly6G(hi)Ly6C(int) neutrophils, suggesting that enteric bacteria restrains activation of some immune components.
Wed Jul 01 00:00:00 UTC 2015
Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia.
PLoS pathogens
Nanjappa SG,Hernández-Santos N,Galles K,Wüthrich M,Suresh M,Klein BS
14-6988 was used in Flow cytometry/Cell sorting to show that T cell-intrinsic MyD88 signals are crucial for these Tc17 cell responses and vaccine immunity against lethal fungal pneumonia in mice.
Tue Sep 01 00:00:00 UTC 2015
Estradiol inhibits Th17 cell differentiation through inhibition of RORγT transcription by recruiting the ERα/REA complex to estrogen response elements of the RORγT promoter.
Journal of immunology (Baltimore, Md. : 1950)
Chen RY,Fan YM,Zhang Q,Liu S,Li Q,Ke GL,Li C,You Z
Wed Apr 15 00:00:00 UTC 2015
Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.
Immunity
Xiao S,Yosef N,Yang J,Wang Y,Zhou L,Zhu C,Wu C,Baloglu E,Schmidt D,Ramesh R,Lobera M,Sundrud MS,Tsai PY,Xiang Z,Wang J,Xu Y,Lin X,Kretschmer K,Rahl PB,Young RA,Zhong Z,Hafler DA,Regev A,Ghosh S,Marson A,Kuchroo VK
Thu Apr 17 00:00:00 UTC 2014
The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
Immunity
Tang W,Wang H,Claudio E,Tassi I,Ha HL,Saret S,Siebenlist U
14-6988 was used in Flow cytometry/Cell sorting to investigate a T-cell-intrinsic function of the transcriptional regulator Bcl-3 in autoimmunity.
Thu Oct 16 00:00:00 UTC 2014
CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.
The Journal of experimental medicine
Longman RS,Diehl GE,Victorio DA,Huh JR,Galan C,Miraldi ER,Swaminath A,Bonneau R,Scherl EJ,Littman DR
14-6988 was used in Flow cytometry/Cell sorting to study the role of CX3CR1+ mononuclear phagocytes in the development of colitis and disease progression following Citrobacter rodentium infection.
Mon Jul 28 00:00:00 UTC 2014
CD5 enhances Th17-cell differentiation by regulating IFN-γ response and RORγt localization.
European journal of immunology
McGuire DJ,Rowse AL,Li H,Peng BJ,Sestero CM,Cashman KS,De Sarno P,Raman C
14-6988 was used in Flow cytometry/Cell sorting to investigate a novel mechanism for the modulation of the generation of Th17 cells.
Tue Apr 01 00:00:00 UTC 2014
CD5 enhances Th17-cell differentiation by regulating IFN-γ response and RORγt localization.
European journal of immunology
McGuire DJ,Rowse AL,Li H,Peng BJ,Sestero CM,Cashman KS,De Sarno P,Raman C
14-6988 was used in Flow cytometry/Cell sorting to investigate a novel mechanism for the modulation of the generation of Th17 cells.
Tue Apr 01 00:00:00 UTC 2014
Akt-dependent enhanced migratory capacity of Th17 cells from children with lupus nephritis.
Journal of immunology (Baltimore, Md. : 1950)
Kshirsagar S,Riedl M,Billing H,Tönshoff B,Thangavadivel S,Steuber C,Staude H,Wechselberger G,Edelbauer M
14-6988 was used in Flow cytometry/Cell sorting to determine that therapeutic modulation of Akt activity could suppress chronic inflammatory processes in children with lupus.
Sat Nov 15 00:00:00 UTC 2014
Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.
Journal of cellular and molecular medicine
Liu HY,Chao H,Liu ZK,Xia HF,Song Z,Yang Y,Peng JP
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Immunohistochemistry (Frozen)
Sat Mar 01 00:00:00 UTC 2014
Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.
Journal of cellular and molecular medicine
Liu HY,Chao H,Liu ZK,Xia HF,Song Z,Yang Y,Peng JP
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Immunohistochemistry (Frozen)
Sat Mar 01 00:00:00 UTC 2014
Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.
Journal of cellular and molecular medicine
Liu HY,Chao H,Liu ZK,Xia HF,Song Z,Yang Y,Peng JP
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Immunohistochemistry (Frozen)
Sat Mar 01 00:00:00 UTC 2014
Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.
Journal of cellular and molecular medicine
Liu HY,Chao H,Liu ZK,Xia HF,Song Z,Yang Y,Peng JP
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Immunohistochemistry (Frozen)
Sat Mar 01 00:00:00 UTC 2014
High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Immunohistochemistry
Thu May 01 00:00:00 UTC 2014
High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Immunohistochemistry
Thu May 01 00:00:00 UTC 2014
The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells.
The Journal of biological chemistry
Han L,Yang J,Wang X,Wu Q,Yin S,Li Z,Zhang J,Xing Y,Chen Z,Tsun A,Li D,Piccioni M,Zhang Y,Guo Q,Jiang L,Bao L,Lv L,Li B
14-6988 was used in Western Blotting to study the regulation of retinoic acid-related orphan nuclear receptor γt expression through deubiquitination.
Fri Sep 12 00:00:00 UTC 2014
The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells.
The Journal of biological chemistry
Han L,Yang J,Wang X,Wu Q,Yin S,Li Z,Zhang J,Xing Y,Chen Z,Tsun A,Li D,Piccioni M,Zhang Y,Guo Q,Jiang L,Bao L,Lv L,Li B
14-6988 was used in Western Blotting to study the regulation of retinoic acid-related orphan nuclear receptor γt expression through deubiquitination.
Fri Sep 12 00:00:00 UTC 2014
Self in vivo production of a synthetic biological drug CTLA4Ig using a minicircle vector.
Scientific reports
Rim YA,Yi H,Kim Y,Park N,Jung H,Kim J,Jung SM,Park SH,Ju JH
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Thu Nov 06 00:00:00 UTC 2014
Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms.
F1000Research
Niebling J,E Rünker A,Schallenberg S,Kretschmer K,Kempermann G
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Fri Mar 06 00:00:00 UTC 2020
Potential role of IL-17-producing iNKT cells in type 1 diabetes.
PloS one
Li S,Joseph C,Becourt C,Klibi J,Luce S,Dubois-Laforgue D,Larger E,Boitard C,Benlagha K
14-6988 was used in Flow cytometry/Cell sorting to investigate the status and potential role of iNKT17 in type 1 diabetes.
Thu Jan 22 00:00:00 UTC 2015
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Nature
Kleinewietfeld M,Manzel A,Titze J,Kvakan H,Yosef N,Linker RA,Muller DN,Hafler DA
14-6988 was used in Flow cytometry/Cell sorting to investigate the environmental factors that influence TH17 cells, showing that sodium chloride induces TH17 cells and drives autoimmune disease.
Thu Apr 25 00:00:00 UTC 2013
Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
Nature immunology
Hirota K,Turner JE,Villa M,Duarte JH,Demengeot J,Steinmetz OM,Stockinger B
14-6988 was used in Flow cytometry/Cell sorting to provide evidence that TH17 cells are the crucial subset required for the production of high-affinity T cell-dependent IgA.
Mon Apr 01 00:00:00 UTC 2013
Identification of transcriptional regulators in the mouse immune system.
Nature immunology
Jojic V,Shay T,Sylvia K,Zuk O,Sun X,Kang J,Regev A,Koller D,Best AJ,Knell J,Goldrath A,Joic V,Koller D,Shay T,Regev A,Cohen N,Brennan P,Brenner M,Kim F,Rao TN,Wagers A,Heng T,Ericson J,Rothamel K,Ortiz-Lopez A,Mathis D,Benoist C,Bezman NA,Sun JC,Min-Oo G,Kim CC,Lanier LL,Miller J,Brown B,Merad M,Gautier EL,Jakubzick C,Randolph GJ,Monach P,Blair DA,Dustin ML,Shinton SA,Hardy RR,Laidlaw D,Collins J,Gazit R,Rossi DJ,Malhotra N,Sylvia K,Kang J,Kreslavsky T,Fletcher A,Elpek K,Bellemarte-Pelletier A,Malhotra D,Turley S
14-6988 was used in Flow cytometry/Cell sorting to study the transcriptional regulators in the mouse immune system.
Sat Jun 01 00:00:00 UTC 2013
Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
Ysebrant de Lendonck L,Tonon S,Nguyen M,Vandevenne P,Welsby I,Martinet V,Molle C,Charbonnier LM,Leo O,Goriely S
14-6988 was used in Immunofluorescence to assess the contribution of IFN regulatory factor 3 to T-cell activation.
Tue Aug 20 00:00:00 UTC 2013
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium.
Mucosal immunology
Manta C,Heupel E,Radulovic K,Rossini V,Garbi N,Riedel CU,Niess JH
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Tue Jan 01 00:00:00 UTC 2013
Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system.
Brain : a journal of neurology
Larochelle C,Cayrol R,Kebir H,Alvarez JI,Lécuyer MA,Ifergan I,Viel É,Bourbonnière L,Beauseigle D,Terouz S,Hachehouche L,Gendron S,Poirier J,Jobin C,Duquette P,Flanagan K,Yednock T,Arbour N,Prat A
14-6988 was used in Flow cytometry/Cell sorting to identify MCAM as a marker of a subset of memory CD4(+) lymphocytes and as a potential marker for multiple sclerosis.
Mon Oct 01 00:00:00 UTC 2012
Mapping of NKp46(+) Cells in Healthy Human Lymphoid and Non-Lymphoid Tissues.
Frontiers in immunology
Tomasello E,Yessaad N,Gregoire E,Hudspeth K,Luci C,Mavilio D,Hardwigsen J,Vivier E
14-6988 was used in Immunofluorescence to establish the basis for analyzing quantitative and qualitative changes of NK cell and ILC subsets in human diseases.
Wed Nov 28 00:00:00 UTC 2012
Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin.
Immunity
Ichiyama K,Sekiya T,Inoue N,Tamiya T,Kashiwagi I,Kimura A,Morita R,Muto G,Shichita T,Takahashi R,Yoshimura A
14-6988 was used in Western Blotting to investigate the molecular mechanisms by which TGF-beta allows Th17 cell differentiation via Smad-independent mechanisms, showing that Eomesodermin is suppressed by TGF-beta via the JNK pathway allowing differentiation.
Fri May 27 00:00:00 UTC 2011
Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin.
Immunity
Ichiyama K,Sekiya T,Inoue N,Tamiya T,Kashiwagi I,Kimura A,Morita R,Muto G,Shichita T,Takahashi R,Yoshimura A
14-6988 was used in Western Blotting to investigate the molecular mechanisms by which TGF-beta allows Th17 cell differentiation via Smad-independent mechanisms, showing that Eomesodermin is suppressed by TGF-beta via the JNK pathway allowing differentiation.
Fri May 27 00:00:00 UTC 2011
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
Nature immunology
El-Behi M,Ciric B,Dai H,Yan Y,Cullimore M,Safavi F,Zhang GX,Dittel BN,Rostami A
14-6988 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which IL-23 promotes pathogenicity of Th17 cells.
Wed Jun 01 00:00:00 UTC 2011
TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B.
Journal of immunology (Baltimore, Md. : 1950)
Gaddis DE,Michalek SM,Katz J
14-6988 was used in Flow cytometry/Cell sorting to investigate how the stimulation of dendritic cells with recombinant haemagglutinin B affects the activation and differentiation of T cells in mice.
Sun May 15 00:00:00 UTC 2011
IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells.
Journal of immunology (Baltimore, Md. : 1950)
Li L,Kim J,Boussiotis VA
Fri Oct 01 00:00:00 UTC 2010
Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections.
Journal of immunology (Baltimore, Md. : 1950)
Henry T,Kirimanjeswara GS,Ruby T,Jones JW,Peng K,Perret M,Ho L,Sauer JD,Iwakura Y,Metzger DW,Monack DM
14-6988 was used in Flow cytometry/Cell sorting to determine that type I IFN signalling might contribute to the resistance of mice to infection with other intracellular bacteria.
Thu Apr 01 00:00:00 UTC 2010
Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells.
Self/nonself
Capurso NA,Look M,Jeanbart L,Nowyhed H,Abraham C,Craft J,Fahmy TM
Published figure using ROR gamma (t) monoclonal antibody (Product # 14-6988-82) in Flow Cytometry
Fri Oct 01 00:00:00 UTC 2010
Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells.
Journal of immunology (Baltimore, Md. : 1950)
Schmutz S,Bosco N,Chappaz S,Boyman O,Acha-Orbea H,Ceredig R,Rolink AG,Finke D
Sat Aug 15 00:00:00 UTC 2009
Lack of IL-6 during coxsackievirus infection heightens the early immune response resulting in increased severity of chronic autoimmune myocarditis.
PloS one
Poffenberger MC,Straka N,El Warry N,Fang D,Shanina I,Horwitz MS
Thu Jul 09 00:00:00 UTC 2009
