Product References
A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in mice.
Frontiers in immunology
Zhu X,Li Q,George V,Spanoudis C,Gilkes C,Shrestha N,Liu B,Kong L,You L,Echeverri C,Li L,Wang Z,Chaturvedi P,Muniz GJ,Egan JO,Rhode PR,Wong HC
17-6981-82 was used in flow cytometry to find that HCW9302 exhibited a longer serum half-life with an approximately 1000-fold higher affinity for the IL-2Rα than IL-2.
Mon Feb 13 00:00:00 UTC 2023
Human gut microbiota stimulate defined innate immune responses that vary from phylum to strain.
Cell host & microbe
Spindler MP,Siu S,Mogno I,Li Z,Yang C,Mehandru S,Britton GJ,Faith JJ
17-6981-82 was used in Flow Cytometry to measure the innate immune responses of myeloid cells to 277 bacterial strains isolated from the gut microbiota of healthy individuals and those with inflammatory bowel diseases.
Wed Oct 12 00:00:00 UTC 2022
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells.
Immunity
Kim E,Paik D,Ramirez RN,Biggs DG,Park Y,Kwon HK,Choi GB,Huh JR
17-6981-82 was used in Flow cytometry/Cell sorting to investigate intestinal inflammation in children with autism spectrum disorders in response to maternal gut bacteria.
Tue Jan 11 00:00:00 UTC 2022
DOCK8-expressing T follicular helper cells newly generated beyond self-organized criticality cause systemic lupus erythematosus.
iScience
Shiozawa S,Tsumiyama K,Miyazaki Y,Uto K,Sakurai K,Nakashima T,Matsuyama H,Doi A,Tarui M,Izumikawa M,Kimura M,Fujita Y,Satonaka C,Horiuchi T,Matsubara T,Oribe M,Yamane T,Kagawa H,Li QZ,Mizuno K,Mukai Y,Murakami K,Enya T,Tsukimoto S,Hakata Y,Miyazawa M,Shiozawa K
17-6981-82 was used in Flow Cytometry to study the induction of systemic autoimmunity in mice normally not prone to autoimmune disease by repeated stimulation with an antigen.
Fri Jan 21 00:00:00 UTC 2022
Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis.
Cell host & microbe
Cao YG,Bae S,Villarreal J,Moy M,Chun E,Michaud M,Lang JK,Glickman JN,Lobel L,Garrett WS
17-6981-82 was used in Flow Cytometry to investigate how microbiota and intestinal epithelial cell (IEC) interactions regulate host physiology in the proximal small intestine, particularly the duodenum.
Wed Sep 14 00:00:00 UTC 2022
Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses.
Immunity
Xu K,Yin N,Peng M,Stamatiades EG,Chhangawala S,Shyu A,Li P,Zhang X,Do MH,Capistrano KJ,Chou C,Leslie CS,Li MO
17-6981-82 was used in Flow cytometry/Cell sorting to show that Warburg metabolism augments glycolytic ATP production, fueling a PI3K-centered positive feedback regulatory circuit that drives effector T cell responses.
Tue May 11 00:00:00 UTC 2021
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
Cellular & molecular immunology
Liu Y,Bockermann R,Hadi M,Safari I,Carrion B,Kveiborg M,Issazadeh-Navikas S
17-6981-82 was used in Flow Cytometry to study the role of ADAM12 in T-cell responses, fate determination on activation, and its functions in T cells to mediate tissue inflammation.
Sun Aug 01 00:00:00 UTC 2021
IL-1β-driven osteoclastogenic Tregs accelerate bone erosion in arthritis.
The Journal of clinical investigation
Levescot A,Chang MH,Schnell J,Nelson-Maney N,Yan J,Martínez-Bonet M,Grieshaber-Bouyer R,Lee PY,Wei K,Blaustein RB,Morris A,Wactor A,Iwakura Y,Lederer JA,Rao DA,Charles JF,Nigrovic PA
17-6981-82 was used in Flow Cytometry to identify IL-1β-induced osteoclastogenic Tregs as a contributor to bone erosion in arthritis.
Wed Sep 15 00:00:00 UTC 2021
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
17-6981-82 was used in Flow Cytometry to show a persistent accumulation of T cells in mice and human autopsy samples for more than 1 mo after stroke.
Mon Aug 02 00:00:00 UTC 2021
Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection.
Nature communications
Zhao Z,Wang H,Shi M,Zhu T,Pediongco T,Lim XY,Meehan BS,Nelson AG,Fairlie DP,Mak JYW,Eckle SBG,de Lima Moreira M,Tumpach C,Bramhall M,Williams CG,Lee HJ,Haque A,Evrard M,Rossjohn J,McCluskey J,Corbett AJ,Chen Z
17-6981-82 was used in Flow Cytometry to highlight the potential utility of targeting MAIT cells to combat a range of bacterial pathogens.
Fri Jul 16 00:00:00 UTC 2021
Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.
Cell reports
Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR
17-6981-82 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.
Tue Aug 24 00:00:00 UTC 2021
Retinoic Acid Induces Functionally Suppressive Foxp3+RORγt+ T Cells In Vitro.
Frontiers in immunology
Martínez-Blanco M,Lozano-Ojalvo D,Pérez-Rodríguez L,Benedé S,Molina E,López-Fandiño R
17-6981-82 was used in Flow Cytometry to show that under the influence of IL-2 and TGF-β, suppressive Foxp3+RORγt+ T cells that express and secrete IL-17 can be produced in vitro and RA further contributes to stabilize this phenotype.
Thu Oct 21 00:00:00 UTC 2021
Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors.
Cell
Burger ML,Cruz AM,Crossland GE,Gaglia G,Ritch CC,Blatt SE,Bhutkar A,Canner D,Kienka T,Tavana SZ,Barandiaran AL,Garmilla A,Schenkel JM,Hillman M,de Los Rios Kobara I,Li A,Jaeger AM,Hwang WL,Westcott PMK,Manos MP,Holovatska MM,Hodi FS,Regev A,Santagata S,Jacks T
17-6981-82 was used in Flow cytometry/Cell sorting to conclude that vaccination eliminated CCR6+ TCF1+ cells and dramatically improved the subdominant response, highlighting a strategy to optimally engage concurrent neoantigen responses against tumors.
Thu Sep 16 00:00:00 UTC 2021
Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.
Cell
Lai NY,Musser MA,Pinho-Ribeiro FA,Baral P,Jacobson A,Ma P,Potts DE,Chen Z,Paik D,Soualhi S,Yan Y,Misra A,Goldstein K,Lagomarsino VN,Nordstrom A,Sivanathan KN,Wallrapp A,Kuchroo VK,Nowarski R,Starnbach MN,Shi H,Surana NK,An D,Wu C,Huh JR,Rao M,Chiu IM
17-6981-82 was used in Flow Cytometry to reveal a major role for nociceptor neurons in sensing and defending against enteric pathogens.
Thu Jan 09 00:00:00 UTC 2020
Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression.
Circulation research
Sharma M,Schlegel MP,Afonso MS,Brown EJ,Rahman K,Weinstock A,Sansbury BE,Corr EM,van Solingen C,Koelwyn GJ,Shanley LC,Beckett L,Peled D,Lafaille JJ,Spite M,Loke P,Fisher EA,Moore KJ
17-6981 was used in Flow cytometry/Cell sorting to establish essential roles for Tregs in resolving atherosclerotic cardiovascular disease and provide mechanistic insight into the pathways governing plaque remodeling and regression of disease.
Fri Jul 17 00:00:00 UTC 2020
Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2.
The Journal of experimental medicine
Fachi JL,Sécca C,Rodrigues PB,Mato FCP,Di Luccia B,Felipe JS,Pral LP,Rungue M,Rocha VM,Sato FT,Sampaio U,Clerici MTPS,Rodrigues HG,Câmara NOS,Consonni SR,Vieira AT,Oliveira SC,Mackay CR,Layden BT,Bortoluci KR,Colonna M,Vinolo MAR
17-6981 was used in Flow cytometry/Cell sorting to study the impact of a microbiota-derived metabolite, short-chain fatty acid acetate, on an acute mouse model of CDI.
Mon Mar 02 00:00:00 UTC 2020
Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells.
Nature communications
Harsha Krovi S,Zhang J,Michaels-Foster MJ,Brunetti T,Loh L,Scott-Browne J,Gapin L
17-6981 was used in Flow cytometry/Cell sorting to highlight the common requirements for the development of innate-like T cells with a focus on how Hivep3 impacts the maturation of these lymphocytes.
Mon Dec 07 00:00:00 UTC 2020
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.
Nature communications
Yang W,Yu T,Huang X,Bilotta AJ,Xu L,Lu Y,Sun J,Pan F,Zhou J,Zhang W,Yao S,Maynard CL,Singh N,Dann SM,Liu Z,Cong Y
17-6981-82 was used in Flow Cytometry to demonstrate that microbiota-derived short-chain fatty acids (SCFAs) promote IL-22 production by CD4+ T cells and ILCs through G-protein receptor 41 (GPR41) and inhibiting histone deacetylase (HDAC).
Tue Sep 08 00:00:00 UTC 2020
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Cell reports
Shin B,Benavides GA,Geng J,Koralov SB,Hu H,Darley-Usmar VM,Harrington LE
17-6981 was used in Flow cytometry/Cell sorting to study the role of mitochondrial oxidative phosphorylation in pathogenic Th17 differentiation.
Tue Feb 11 00:00:00 UTC 2020
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
Cell
Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T
17-6981 was used in Flow cytometry/Cell sorting to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.
Thu Feb 21 00:00:00 UTC 2019
Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells.
Immunity
Pokrovskii M,Hall JA,Ochayon DE,Yi R,Chaimowitz NS,Seelamneni H,Carriero N,Watters A,Waggoner SN,Littman DR,Bonneau R,Miraldi ER
17-6981 was used in Flow cytometry/Cell sorting to study regulatory interactions between transcription factors and genes within intestinal type 1, 2, and 3 innate lymphoid cells subsets.
Tue Jul 16 00:00:00 UTC 2019
Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity.
Immunity
Chun E,Lavoie S,Fonseca-Pereira D,Bae S,Michaud M,Hoveyda HR,Fraser GL,Gallini Comeau CA,Glickman JN,Fuller MH,Layden BT,Garrett WS
17-6981 was used in Flow cytometry/Cell sorting to demonstrate group 3 innate lymphoid cells are regulated by the metabolite-sensing receptor Ffar2.
Tue Nov 19 00:00:00 UTC 2019
Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1.
The EMBO journal
Clancy-Thompson E,Chen GZ,LaMarche NM,Ali LR,Jeong HJ,Crowley SJ,Boelaars K,Brenner MB,Lynch L,Dougan SK
17-6981-82 was used in Flow cytometry/Cell sorting to show that iNKT transnuclear mice, generated by somatic cell nuclear transfer, have increased tissue resident iNKT cells.
Mon Jul 15 00:00:00 UTC 2019
CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Nature communications
Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM
17-6981-82 was used in Flow cytometry/Cell sorting to show that CD160 is not essential for NKT cell development.
Mon Jul 22 00:00:00 UTC 2019
Contribution of LTi and TH17 cells to B cell aggregate formation in the central nervous system in a mouse model of multiple sclerosis.
Journal of neuroinflammation
Schropp V,Rohde J,Rovituso DM,Jabari S,Bharti R,Kuerten S
17-6981-82 was used in Flow Cytometry to propose some potential candidates, which might be involved in the formation of B cell aggregates in the CNS of MP4-immunized mice.
Tue May 28 00:00:00 UTC 2019
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
Nature communications
Scheer S,Ackloo S,Medina TS,Schapira M,Li F,Ward JA,Lewis AM,Northrop JP,Richardson PL,Kaniskan HÜ,Shen Y,Liu J,Smil D,McLeod D,Zepeda-Velazquez CA,Luo M,Jin J,Barsyte-Lovejoy D,Huber KVM,De Carvalho DD,Vedadi M,Zaph C,Brown PJ,Arrowsmith CH
17-6981 was used in Flow cytometry/Cell sorting to present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine protein methyltransferases in cellular studies.
Thu Jan 03 00:00:00 UTC 2019
IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection.
Nature communications
Frisbee AL,Saleh MM,Young MK,Leslie JL,Simpson ME,Abhyankar MM,Cowardin CA,Ma JZ,Pramoonjago P,Turner SD,Liou AP,Buonomo EL,Petri WA
17-6981-82 was used in Flow Cytometry to identify potential therapeutic immune pathways that aid in recovery during infection with the hypervirulent strain of Clostridium difficile, R20291.
Thu Jun 20 00:00:00 UTC 2019
Netrin-1 Alters Adipose Tissue Macrophage Fate and Function in Obesity.
Immunometabolism
Sharma M,Schlegel M,Brown EJ,Sansbury BE,Weinstock A,Afonso MS,Corr EM,van Solingen C,Shanley LC,Peled D,Ramasamy R,Schmidt AM,Spite M,Fisher EA,Moore KJ
17-6981-82 was used in Flow Cytometry to show that targeted deletion of netrin-1 in macrophages reprograms the ATM phenotype in obesity, leading to reduced adipose inflammation, and improved lipid handling and metabolic function.
Wed Sep 30 00:00:00 UTC 2020
Characterization and Purification of Mouse Mucosal-Associated Invariant T (MAIT) Cells.
Current protocols in immunology
Chen Z,Wang H,D'Souza C,Koay HF,Meehan B,Zhao Z,Pediongco T,Shi M,Zhu T,Wang B,Kjer-Nielsen L,Eckle SBG,Rossjohn J,Fairlie DP,Godfrey DI,Strugnell RA,McCluskey J,Corbett AJ
17-6981-82 was used in Flow cytometry/Cell sorting to provide a step-by-step protocol for mucosal-associated invariant T (MAIT) cell sorting and adoptive transfer.
Sun Dec 01 00:00:00 UTC 2019
Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses.
JCI insight
Lee CG,Kwon HK,Kang H,Kim Y,Nam JH,Won YH,Park S,Kim T,Kang K,Rudra D,Jun CD,Park ZY,Im SH
17-6981 was used in Flow cytometry/Cell sorting to reveal a protective role of Ets1 in restricting pathogenic Th cell responses and suggest a potential therapeutic target for atopic dermatitis (AD) treatment.
Thu Mar 07 00:00:00 UTC 2019
The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response.
eLife
Lavoie S,Conway KL,Lassen KG,Jijon HB,Pan H,Chun E,Michaud M,Lang JK,Gallini Comeau CA,Dreyfuss JM,Glickman JN,Vlamakis H,Ananthakrishnan A,Kostic A,Garrett WS,Xavier RJ
17-6981 was used in Flow cytometry/Cell sorting to unravel the effects of ATG16L1 T300A on the microbiota and immune system, employing a gnotobiotic model using human fecal transfers into ATG16L1 T300A knock in mice.
Tue Jan 22 00:00:00 UTC 2019
Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis.
Immunity
Grizotte-Lake M,Zhong G,Duncan K,Kirkwood J,Iyer N,Smolenski I,Isoherranen N,Vaishnava S
17-6981 was used in Flow cytometry/Cell sorting to define a regulatory circuit wherein bacterial regulation of IEC-intrinsic RA synthesis protects microbial communities in the gut from excessive immune activity, achieving a balance that prevents colonization by enteric pathogens.
Tue Dec 18 00:00:00 UTC 2018
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.
Nature
Kim S,Kim H,Yim YS,Ha S,Atarashi K,Tan TG,Longman RS,Honda K,Littman DR,Choi GB,Huh JR
17-6981 was used in Flow cytometry/Cell sorting to suggest that defined gut commensal bacteria with a propensity to induce TH17 cells may increase the risk of neurodevelopmental disorders in the offspring of pregnant mothers undergoing immune system activation owing to infections or autoinflammatory syndromes.
Thu Sep 28 00:00:00 UTC 2017
T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination.
Frontiers in immunology
Hemmi M,Tachibana M,Fujimoto N,Shoji M,Sakurai F,Kobiyama K,Ishii KJ,Akira S,Mizuguchi H
17-6981 was used in Flow cytometry/Cell sorting to study how Th17 cells translate systemic type I interferon signalling into a gut-mucosal cytotoxic T lymphocyte response following adenoviral vector vaccination.
Wed Nov 20 00:00:00 UTC 2019
Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice.
Mucosal immunology
Sun T,Rojas OL,Li C,Ward LA,Philpott DJ,Gommerman JL
17-6981 was used in Flow cytometry/Cell sorting to study the dendritic cell subset(s) that provoke antiviral responses within the gut.
Mon May 01 00:00:00 UTC 2017
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.
PLoS pathogens
Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M
17-6981 was used in Flow cytometry/Cell sorting to suggest that MyD88 signaling in DC and IEC is both essential and sufficient to induce a full spectrum of host responses upon intestinal infection with C. rodentium.
Mon May 01 00:00:00 UTC 2017
Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Yi P,Tang H,Soong L,Cong Y,Zhang K,Sun J
17-6981 was used in Flow cytometry/Cell sorting to determine the role of retinoic acid in IL-22 production during hepatitis infection.
Mon May 01 00:00:00 UTC 2017
Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets.
Journal of immunology (Baltimore, Md. : 1950)
Clancy-Thompson E,Chen GZ,Tyler PM,Servos MM,Barisa M,Brennan PJ,Ploegh HL,Dougan SK
17-6981 was used in Flow cytometry/Cell sorting to examine how T cell receptor specificity determines invariant natural killer T cell function.
Sat Jul 01 00:00:00 UTC 2017
RORγt-expressing cells attenuate cardiac remodeling after myocardial infarction.
PloS one
Enomoto D,Matsumoto K,Yamashita T,Kobayashi A,Maeda M,Nakayama H,Obana M,Fujio Y
17-6981 was used in Flow cytometry/Cell sorting to demonstrate that heterozygous deletion of Retinoic acid receptor-related orphan nuclear receptor γt (RORγt) results in aggravated cardiac remodeling and reduced capillary density following myocardial infarction, suggesting a role in tissue repair.
Fri Oct 13 00:00:00 UTC 2017
Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.
JCI insight
Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N
17-6981 was used in Flow cytometry/Cell sorting to identify functionally distinct adaptive GPCR heterogeneity patternation in mice.
Thu Aug 03 00:00:00 UTC 2017
CD4(+) T-cell survival in the GI tract requires dectin-1 during fungal infection.
Mucosal immunology
Drummond RA,Dambuza IM,Vautier S,Taylor JA,Reid DM,Bain CC,Underhill DM,Masopust D,Kaplan DH,Brown GD
17-6981 was used in Flow cytometry/Cell sorting to study the role of Dectin-1 in the coordination of fungal-specific CD4(+) T-cell responses in the GI tract.
Tue Mar 01 00:00:00 UTC 2016
Interleukin (IL)-21 promotes intestinal IgA response to microbiota.
Mucosal immunology
Cao AT,Yao S,Gong B,Nurieva RI,Elson CO,Cong Y
17-6981 was used in Flow cytometry/Cell sorting to investigate the role of Th17 and Tfh cytokines in regulating the mucosal IgA response to enteric microbiota.
Tue Sep 01 00:00:00 UTC 2015
Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Hou L,Dong C,Iwakura Y,Soong L,Cong Y,Sun J
17-6981 was used in Flow cytometry/Cell sorting to investigate the source and regulation of the IL-17 surge in the liver microenvironment that occurs early in the response to viral infection.
Tue Apr 01 00:00:00 UTC 2014
