Invitrogen

ROR1 Polyclonal Antibody

产品信息

PA5-50830

应用	建议稀释比	已发表文章
免疫组化（石蜡） (IHC (P))	1:25-1:100	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthetic peptide corresponding to a region derived from internal residues of human receptor tyrosine kinase-like orphan receptor 1
偶联物	Unconjugated
形式	Liquid
浓度	2.6 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 40% glycerol
内含物	0.05% sodium azide
保存条件	-20°C
RRID	AB_2636282

产品详细信息

The antibody detects endogenous levels of total ROR1 protein.

靶标信息

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. Virtually absent from normal pediatric and adult tissues, with the exception of low-level expression in a subset of immature b cell precursors known as hematogones and adipocytes, ROR1 is notably overexpressed, and considered a survival factor, in a number of B lymphoid and epithelial malignancies: including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, lung adenocarcinoma. First identified during PCR-based cloning of a human neuroblastoma cell line in search of tyrosine kinases similar to tropomyosin-receptor-kinase (Trk) neurotropic receptors, ROR1, along with the related receptor tyrosine kinase (RTK) ROR2, was catalogued as an "orphan" receptor due to the fact its related ligand remained elusive. Wnt-5a has since been suggested as a candidate ligand for ROR1, and ROR1 has been implicated to function as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through interaction with Wnt-5a, and TCL1-co-activation of AKT. ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin (Ig)-like, Frizzled, and Kringle domains, as well as an intracellular region containing a tyrosine kinase domain.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Inactive tyrosine-protein kinase transmembrane receptor ROR1; MGC99659; mROR1; neurotrophic tyrosine kinase, receptor related 1; Neurotrophic tyrosine kinase, receptor-related 1; receptor tyrosine kinase-like orphan receptor 1; T-ROR1; tyrosine-protein kinase transmembrane receptor ROR1

基因别名: 2810404D04Rik; dJ537F10.1; mRor1; NTRKR1; ROR1

UniProt ID: (Human) Q01973, (Mouse) Q9Z139

Entrez Gene ID: (Human) 4919, (Mouse) 26563

分子生物学功能: transmembrane signal receptor