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Proteintech
RORC Polyclonal Antibody
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产品信息
13205-1-AP
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RORC Fusion Protein Ag3961 (165-518 aa encoded by BC031554)
偶联物
形式
Liquid
浓度
0.15 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: DLPEASACP PGLLKASGSG PSYSNNLAKA GLNGASCHLE YSPERGKAEG RESFYSTGSQ LTPDRCGLRF EEHRHPGLGE LGQGPDSYGS PSFRSTPEAP YASLTEIEHL VQSVCKSYRE TCQLRLEDLL RQRSNIFSRE EVTGYQRKSM WEMWERCAHH LTEAIQYVVE FAKRLSGFME LCQNDQIVLL KAGAMEVVLV RMCRAYNADN RTVFFEGKYG GMELFRALGC SELISSIFDF SHSLSALHFS EDEIALYTAL VLINAHRPGL QEKRKVEQLQ YNLELAFHHH LCKTHRQSIL AKLPPKGKLR SLCSQHVERL QIFQHLHPIV VQAAFPPLYK ELFSTETESP VGLSK (165-518 aa encoded by BC031554)
靶标信息
ROR gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. Reports suggest thatROR gammais a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR gamma shares 50 to 51% sequence identity with RORA and RORB and is 88% identical to mouse ROR gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
