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Proteintech
RRP8 Polyclonal Antibody
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产品信息
20129-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RRP8 Fusion Protein Ag13994 (97-456 aa encoded by BC001071)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: QKQGPPCSD SEEEVERKKK CHKQALVGSD SAEDEKRKRK CQKHAPINSA QHLDNVDQTG PKAWKGSTTN DPPKQSPGST SPKPPHTLSR KQWRNRQKNK RRCKNKFQPP QVPDQAPAEA PTEKTEVSPV PRTDSHEARA GALRARMAQR LDGARFRYLN EQLYSGPSSA AQRLFQEDPE AFLLYHRGFQ SQVKKWPLQP VDRIARDLRQ RPASLVVADF GCGDCRLASS IRNPVHCFDL ASLDPRVTVC DMAQVPLEDE SVDVAVFCLS LMGTNIRDFL EEANRVLKPG GLLKVAEVSS RFEDVRTFLR AVTKLGFKIV SKDLTNSHFF LFDFQKTGPP LVGPKAQLSG LQLQPCLYKR R (97-456 aa encoded by BC001071)
靶标信息
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cerebral protein 1; Cerebral protein 1 homolog; HUCE1; hucep1; Nucleomethylin; Ribosomal RNA-processing protein 8; RRP-8; RRP8 methyltransferase homolog
基因别名: 1500003O22Rik; 2900001K19Rik; AW538116; hucep-1; KIAA0409; NML; RGD1308302; RRP8
UniProt ID: (Human) O43159, (Mouse) Q9DB85, (Rat) Q5U4F0
Entrez Gene ID: (Human) 23378, (Mouse) 101867, (Rat) 308911
protein binding
S-adenosylmethionine-dependent methyltransferase activity
methylated histone binding
poly(A) RNA binding
rRNA (adenine-N6,N6-)-dimethyltransferase activity
protein C-terminal carboxyl O-methyltransferase activity
tRNA (guanine-N2-)-methyltransferase activity
methyltransferase activity
C-methyltransferase activity
N-methyltransferase activity
O-methyltransferase activity
S-methyltransferase activity
RNA methyltransferase activity
mRNA methyltransferase activity
tRNA methyltransferase activity
protein methyltransferase activity
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
rRNA methyltransferase activity
rRNA (uridine-2'-O-)-methyltransferase activity
rRNA (adenine-N6-)-methyltransferase activity
DNA-methyltransferase activity
tRNA (guanine-N1-)-methyltransferase activity
rRNA (cytosine-C5-)-methyltransferase activity
selenocysteine methyltransferase activity
arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
lysine N-methyltransferase activity
protein-lysine N-methyltransferase activity
tRNA (uracil) methyltransferase activity
tRNA (guanine) methyltransferase activity
tRNA (adenine) methyltransferase activity
tRNA (cytosine) methyltransferase activity
tRNA (cytosine-5-)-methyltransferase activity
tRNA (adenine-N1-)-methyltransferase activity
rRNA (adenine) methyltransferase activity
rRNA (cytosine) methyltransferase activity
rRNA (guanine) methyltransferase activity
rRNA (uridine) methyltransferase activity
transferase activity
protein C-terminal leucine carboxyl O-methyltransferase activity
1-phenanthrol methyltransferase activity
protein-arginine N5-methyltransferase activity
methylarsonite methyltransferase activity
dimethylarsinite methyltransferase activity
4,5-dihydroxybenzo(a)pyrene methyltransferase activity
1-hydroxypyrene methyltransferase activity
1-hydroxy-6-methoxypyrene methyltransferase activity
demethylmenaquinone methyltransferase activity
cobalt-precorrin-6B C5-methyltransferase activity
cobalt-precorrin-7 C15-methyltransferase activity
cobalt-precorrin-5B C1-methyltransferase activity
cobalt-precorrin-3 C17-methyltransferase activity
dimethylamine methyltransferase activity
hydroxyneurosporene-O-methyltransferase activity
tRNA (adenine-57, 58-N(1)-) methyltransferase activity
methylamine-specific methylcobalamin:coenzyme M methyltransferase activity
trimethylamine methyltransferase activity
methanol-specific methylcobalamin:coenzyme M methyltransferase activity
monomethylamine methyltransferase activity
P-methyltransferase activity
Se-methyltransferase activity
2-phytyl-1,4-naphthoquinone methyltransferase activity
tRNA (uracil-2'-O-)-methyltransferase activity
tRNA (cytosine-2'-O-)-methyltransferase activity
phosphomethylethanolamine N-methyltransferase activity
tRNA (cytosine-3-)-methyltransferase activity
rRNA (cytosine-2'-O-)-methyltransferase activity
rRNA (cytosine-N4-)-methyltransferase activity
trihydroxyferuloyl spermidine O-methyltransferase activity
chromatin silencing at rDNA
transcription, DNA-templated
rRNA processing
covalent chromatin modification
methylation
cellular response to glucose starvation
regulation of transcription by glucose
positive regulation of cell cycle arrest
intrinsic apoptotic signaling pathway by p53 class mediator
regulation of transcription, DNA-templated
chromatin modification
