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Invitrogen
RSPO2 Monoclonal Antibody (CL14321)
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产品信息
MA563027
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
CL14321
抗原
Recombinant protein corresponding to Human RSPO2
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
靶标信息
The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally-related, secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. This activity effectively activates and increases the subsequent nuclear signaling of beta-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/beta-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cristin-2; Cysteine-rich and single thrombospondin domain-containing protein 2; hRspo2; mCristin-2; R-spondin 2 homolog; R-spondin-2; Roof plate-specific spondin-2
基因别名: 2610028F08Rik; AA673245; CRISTIN2; D430027K22; ftls; RSPO2; UNQ9384/PRO34209
UniProt ID: (Human) Q6UXX9, (Mouse) Q8BFU0
Entrez Gene ID: (Human) 340419, (Mouse) 239405
osteoblast differentiation
Wnt signaling pathway
positive regulation of Wnt signaling pathway
bone mineralization
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
negative regulation of odontogenesis of dentin-containing tooth
lung growth
epithelial tube branching involved in lung morphogenesis
trachea cartilage morphogenesis
dopaminergic neuron differentiation
positive regulation of canonical Wnt signaling pathway
response to stimulus
