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Invitrogen
RT1.D Monoclonal Antibody (OX-17)
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产品信息
MA1-70009
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OX-17
抗原
Rat spleen membrane glycoproteins depleted of Ia-A antigens
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
靶标信息
RT1.D is a gene located within the major histocompatibility complex (MHC) region of the rat genome, specifically part of the RT1 complex. RT1.D, along with its counterpart RT1.B, comprises class II MHC genes, which are key players in the adaptive immune response. These genes encode for proteins that present extracellularly derived peptides to helper T cells (CD4+ T cells), facilitating the activation and regulation of immune responses. The RT1.D gene product is analogous to human HLA-DR and mouse I-A/I-E molecules, playing an essential role in antigen presentation and immune recognition. RT1.D genes are highly polymorphic, which influences susceptibility to various diseases and are often utilized in studies involving autoimmune diseases, immune response, and transplantation immunology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MHC class II RT1D beta1 chain antigen; rano class II histocompatibility antigen, D-1 beta chain; rat class I D; RT1 class II histocompatibility antigen, D-1 beta chain; RT1-D beta
基因别名: Db1; RT1-Db; RT1-Db1n
Entrez Gene ID: (Rat) 294270
immunoglobulin production involved in immunoglobulin mediated immune response
inflammatory response to antigenic stimulus
humoral immune response mediated by circulating immunoglobulin
peptide antigen assembly with MHC class II protein complex
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
polysaccharide assembly with MHC class II protein complex
negative regulation of inflammatory response to antigenic stimulus
immune response
biological_process
detection of bacterium
antigen processing and presentation of exogenous peptide antigen via MHC class II
regulation of interleukin-4 production
negative regulation of interferon-gamma production
response to interferon-gamma
positive regulation of insulin secretion involved in cellular response to glucose stimulus
T-helper 1 type immune response
negative regulation of T cell proliferation
protein tetramerization
regulation of interleukin-10 secretion
