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Invitrogen
RT1.D Monoclonal Antibody (OX-17), Biotin
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-17435
产品规格
种属反应
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OX-17
抗原
Rat spleen membrane glycoproteins depleted of Ia-A antigens.
偶联物
Biotin
Biotin
Biotin
形式
Liquid
浓度
0.1 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS with 4-5mg/mL BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
anti-rat RT1.D monoclonal antibody recognizes a monomorphic determinant on the α chain of the rat Ia antigen and appears to be the rat homologue of mouse Ia-E. It recognizes the rat Ia product present on B, but not T cells from lymph node or thoracic duct lymph. It does not bind to thymocytes or erythrocytes. The antibody does not cross-react with rat Ia-A or mouse Ia-E antigen, but rabbit antibody raised against the antibody affinity column-purified MRC OX-17 antigen cross-reacted on tissues of mice expressing Ia-E mouse antigen but not on those mouse strains that were Ia-E antigen negative.
靶标信息
RT1.D is a gene located within the major histocompatibility complex (MHC) region of the rat genome, specifically part of the RT1 complex. RT1.D, along with its counterpart RT1.B, comprises class II MHC genes, which are key players in the adaptive immune response. These genes encode for proteins that present extracellularly derived peptides to helper T cells (CD4+ T cells), facilitating the activation and regulation of immune responses. The RT1.D gene product is analogous to human HLA-DR and mouse I-A/I-E molecules, playing an essential role in antigen presentation and immune recognition. RT1.D genes are highly polymorphic, which influences susceptibility to various diseases and are often utilized in studies involving autoimmune diseases, immune response, and transplantation immunology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MHC class II RT1D beta1 chain antigen; rat class I D; RT1 class II; RT1 class II histocompatibility antigen, D-1 beta chain; RT1-D beta; unnamed protein product
基因别名: Db1; RT1-Db; RT1-Db1n
Entrez Gene ID: (Rat) 294270
positive regulation of T cell mediated cytotoxicity
inflammatory response to antigenic stimulus
myeloid dendritic cell antigen processing and presentation
antigen processing and presentation of endogenous peptide antigen via MHC class II
peptide antigen assembly with MHC class II protein complex
positive regulation of T cell mediated immune response to tumor cell
negative regulation of inflammatory response to antigenic stimulus
immune response
humoral immune response
signal transduction
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
macrophage differentiation
regulation of interleukin-10 production
regulation of interleukin-4 production
negative regulation of interferon-gamma production
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
positive regulation of insulin secretion involved in cellular response to glucose stimulus
T-helper 1 type immune response
negative regulation of T cell proliferation
positive regulation of memory T cell differentiation
regulation of T-helper cell differentiation
positive regulation of monocyte differentiation
positive regulation of immune response
T cell receptor signaling pathway
positive regulation of T cell activation
protein tetramerization
response to dexamethasone
positive regulation of CD4-positive, alpha-beta T cell activation
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