Proteintech

RXRA Recombinant Rabbit Monoclonal Antibody (240878A9)

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说明书
实验方案
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实验方案
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产品信息

83796-5-RR

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:2,000-1:10,000
-

流式细胞分析 (Flow)

0.25 µg/10^6 cells in a 100 µL suspension
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-

Surface plasmon resonance (SPR)

Assay-dependent
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

240878A9

抗原

RXRA fusion protein Ag15651

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Immunogen sequence: LNGVLKVPA HPSGNMASFT KHICAICGDR SSGKHYGVYS CEGCKGFFKR TVRKDLTYTC RDNKDCLIDK RQRNRCQYCR YQKCLAMGMK REAVQEERQR GKDRNENEVE STSSANEDMP VERILEAELA VEPKTETYVE ANMGLNPSSP NDPVTNICQA ADKQLFTLVE WAKRIPHFSE LPLDDQVILL RAGWNELLIA SFSHRSIAVK DGILLATGLH VHRNSAHSAG VGAIFDRVLT ELVSKMRDMQ MDKTELGCLR AIVLFNPDSK GLSNPAEVEA LREKVYASLE AYCKHKYPEQ PGRFAKLLLR LPALRSIGLK CLEHLFFFKL IGDTPIDTFL MEMLEAPHQM T

靶标信息

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; retinoid X receptor; Retinoid X receptor alpha; retinoid X receptor, alpha; rxr alpha; RXR alpha 1

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基因别名: 9530071D11Rik; NR2B1; RXRA; RXRalpha1

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UniProt ID: (Human) P19793, (Mouse) P28700

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Entrez Gene ID: (Human) 6256, (Mouse) 20181

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功能
RNA polymerase II regulatory region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity retinoic acid receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding 9-cis retinoic acid receptor activity protein binding zinc ion binding enzyme binding protein domain specific binding chromatin DNA binding protein complex binding vitamin D receptor binding retinoic acid receptor binding sequence-specific DNA binding transcription regulatory region DNA binding retinoic acid-responsive element binding protein heterodimerization activity vitamin D response element binding double-stranded DNA binding transcription factor binding metal ion binding C4 zinc finger nuclear receptor
参与通路
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development liver development maternal placenta development transcription initiation from RNA polymerase II promoter vitamin metabolic process inflammatory response midgut development embryo implantation aging cholesterol metabolic process negative regulation of cell proliferation response to selenium ion bile acid and bile salt transport modulation by virus of host morphology or physiology axon regeneration regulation of myelination response to retinoic acid cellular response to insulin stimulus response to vitamin A response to vitamin D peroxisome proliferator activated receptor signaling pathway camera-type eye development positive regulation of apoptotic process steroid hormone mediated signaling pathway cellular lipid metabolic process response to ethanol positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation by iron retinoic acid receptor signaling pathway protein homotetramerization response to glucocorticoid ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development regulation of branching involved in prostate gland morphogenesis positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus placenta development heart morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter heart development negative regulation of gene expression positive regulation of transcription, DNA-templated cardiac muscle cell differentiation mesenchyme development angiogenesis involved in coronary vascular morphogenesis visceral serous pericardium development
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