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Invitrogen
RXRB Polyclonal Antibody
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产品信息
PA1-815
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Bovine,
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues Q(190) K S D Q G V E G P G A T(202) of mouse RXR beta.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
whole serum
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-815 detects retinoid X receptor (RXR) beta from human and mouse cells as well as transfected human and mouse RXR beta.
PA1-815 has been successfully used in Western blot, immunoprecipitation and gel shift procedures. By Western blot, this antibody detects an ~50 kDa protein representing RXR beta from COS cells transfected with the human gene. Gel shift assays reveal supershifting of vitamin D receptor (VDR)/RXR beta/vitamin D receptor response element (VDRE) complexes when PA1-815 is preincubated with RXR beta prior to addition of VDR.
The PA1-815 immunogen is a synthetic peptide corresponding to residues Q(190) K S D Q G V E G P G A T(202) of mouse RXR beta.
Recombinant human VDR (Cat. # RP-710) and human RXR beta (catalog # RP-812) proteins can be purchased separately for control experiments in Western blot, immunoprecipitation and gel shift procedures.
靶标信息
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DADB-100D22.1; MGC1831; MHC class I promoter binding protein; MHC class I regulatory element-binding protein H-2RIIBP; Nuclear receptor subfamily 2 group B member 2; putative retinoid X receptor beta; Retinoic acid receptor RXR-beta; retinoid X receptor; Retinoid X receptor beta; retinoid X receptor, beta; RXR Beta
基因别名: AL023085; DAUDI6; H-2RIIBP; NR2B2; RCoR-1; Rub; RXRB
UniProt ID: (Human) P28702, (Mouse) P28704
Entrez Gene ID: (Human) 6257, (Mouse) 20182
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
9-cis retinoic acid receptor activity
protein binding
zinc ion binding
thyroid hormone receptor coactivator activity
vitamin D receptor binding
retinoic acid receptor binding
thyroid hormone receptor binding
protein heterodimerization activity
RNA polymerase II distal enhancer sequence-specific DNA binding
DNA binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
metal ion binding
C4 zinc finger nuclear receptor
transcription initiation from RNA polymerase II promoter
regulation of myelination
steroid hormone mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
positive regulation of receptor activity
in utero embryonic development
maternal placenta development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
ventricular cardiac muscle cell differentiation
cardiac muscle cell proliferation
cellular response to retinoic acid
