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Invitrogen
RXRB Monoclonal Antibody (MOK13-17)
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RXRB Antibody (MA3-812) in IHC
Diabetes 2010 -
FIG. 2. Islet-specific induction of RXRbetaDeltaC2 in the Ins-rtTA/TetO-RXRbetaDeltaC2 double-Tg mice. The total RNA of the pancreas and other organs was subjected to RT-PCR analyses. The rtTA transgene expression was detected only in the pancreas samples from three different Tg mice and not in the other organs or in the non-Tg pancreas ( A , upper panel ). Hypoxanthine-guanine phosphoribosyltransferase (HP... View More
产品信息
MA3-812
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human,
Mouse,
Non-human primate,
Rabbit,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
MOK13-17
抗原
Recombinant human retinoic X receptor beta protein.
偶联物
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
MA3-812 detects retinoid X receptor (RXR) beta from human and mouse tissues. This antibody is specific for the RXR beta isoform and does not cross react with either RXR alpha or gamma.
MA3-812 has been successfully used in Western blot, immunofluorescence, immunoprecipitation and gel shift procedures. By Western blot, this antibody detects an ~50 kDa protein representing RXR beta from transfected Sf9 cells. Immunofluorescence staining of RXR beta in MCF-7 cells overexpressing RXR beta with MA3-812 results in strong nuclear staining. Gel super shift experiments show disruption of vitamin D receptor (VDR)/RXR beta/VDRE (DNA) complex formation when RXR beta was preincubated with MA3-812, yet experiments using THR showed a supershift of the thyroid hormone receptor (THR)/RXR beta heterodimer by this product.
The MA3-812 antigen is recombinant human RXR beta.
靶标信息
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
