Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
应用 | 建议稀释比 | 已发表文章 |
---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
产品规格 | |
---|---|
种属反应 |
Rat |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Lyophilized |
浓度 |
0.5 mg/mL |
纯化类型 |
purified |
内含物 |
no preservative |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
PEP-271 is a 14 amino acid synthetic peptide whose sequence corresponds to residues 113-126 of rat LXR beta. The sequence of this peptide is (amino to carboxy terminus): R113-Y-A-C-R-G-S-G-T-C-Q-M-D-A126
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, LXR beta, catalog # PA1-333. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Liver X receptor beta; nuclear orphan receptor LXR-beta; Nuclear receptor subfamily 1 group H member 2; Orphan nuclear receptor OR-1; Oxysterols receptor LXR-beta; ubiquitous receptor; Ubiquitously-expressed nuclear receptor; UR
基因别名: Lxrb; Nr1h2; OR-1
UniProt ID: (Rat) Q62755
Entrez Gene ID: (Rat) 58851