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产品信息
PEP-194
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Rat |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Lyophilized |
浓度 |
0.5 mg/mL |
纯化类型 |
purified |
内含物 |
no preservative |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
产品详细信息
PEP-194 is a 20 amino acid synthetic peptide. The sequence of this peptide is (amino to carboxy terminus): C (362) W R K R Q P R (R/L) E E R K A P E S Q E D (NH2) (380).
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, catalog # PA1-075. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
Able to phosphorylate several exogenous substrates and to undergo autophosphorylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: advanced glycosylation end product-specific receptor; advanced glycosylation end product-specific receptor variant 2; advanced glycosylation end product-specific receptor variant 3; advanced glycosylation end product-specific receptor variant 4; advanced glycosylation end product-specific receptor variant 5; RAGE-4 ORF3; receptor for advanced glycosylation end products; sRAGE
基因别名: RAGE
Entrez Gene ID: (Rat) 81722
分子生物学功能:
cell adhesion molecule
immunoglobulin superfamily cell adhesion molecule
response to hypoxia
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
negative regulation of endothelial cell proliferation
inflammatory response
negative regulation of cell adhesion
JAK-STAT cascade
brain development
glycoprotein metabolic process
response to fructose
positive regulation of autophagy
negative regulation of endothelial cell migration
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
positive regulation of fibroblast migration
response to activity
positive regulation of smooth muscle cell migration
lung development
positive regulation of cell migration
neuron projection development
negative regulation of collagen biosynthetic process
response to vitamin A
response to genistein
negative regulation of osteoblast proliferation
cellular response to drug
positive regulation of apoptotic process
positive regulation of JUN kinase activity
positive regulation of neuron apoptotic process
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
regulation of inflammatory response
positive regulation of inflammatory response
induction of positive chemotaxis
positive regulation of NF-kappaB transcription factor activity
regulation of DNA binding
response to methylglyoxal
calcium ion homeostasis
response to hyperoxia
positive regulation of phagocytosis, engulfment
transdifferentiation
cellular response to hydrogen peroxide
cellular response to glucose stimulus
cellular response to fatty acid
cellular response to organic cyclic compound
protein localization to membrane
response to selenite ion
positive regulation of potassium ion transmembrane transporter activity
positive regulation of neuron death
positive regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
positive regulation of type B pancreatic cell apoptotic process
