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Invitrogen
RbAp46 Polyclonal Antibody, Biotin
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RbAp46 Antibody (PA1-1868) in WB
Western blot analysis was performed on nuclear enriched extracts (30 µg lysate) of HeLa (Lane 1), MCF7 (Lane 2), MDA-MB-231 (Lane 3), HEK 293 (Lane 4), SW480 (Lane 5), HT-29 (Lane 6), SH-SY5Y (Lane 7), F9 (Lane 8) and T47D (Lane 9). The blot was probed with Rabbit Anti-RbAp46 Polyclonal Antibody (Product # PA1-1868, 2 µg/mL) and detected by chemiluminescence. A 50 kDa band corresponding to RbAp46 was observed across the cell lines tested. Known quantity of protein samples were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Produ... View More
产品信息
PA1-1868
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1.1-868 detects retinoblastoma protein (Rb) associated protein 46 from human cells.
PA1.1-868 has been successfully used in Western blot, ICC/IF and IHC applications. By Western blot, this antibody detects an ~46 kDa protein representing RbAp46 Biotin from HeLa cell lysate
The PA1.1-868 immunogen is a synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46. This sequence is completely conserved between human and mouse. PA1.1-868 immunizing peptide (Cat. # PEP-083) is available for use in neutralization and control experiments.
靶标信息
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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