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Invitrogen
Ricin alpha VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1149)
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产品信息
MA5-54278
产品规格
种属反应
Plant
宿主/亚型
Alpaca
/ VHH
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
SAA1149
抗原
Recombinant Castor bean Ricin.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Metal-chelate chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Compatible with Direct ELISA
靶标信息
Ricin toxin (RCA60), is a 60 kDa glycoprotein that consists of two chains, A and B, covalently linked by disulfide bond. The A chain acts as a glycosidase that removes an adenine residue from the 28S rRNA. The area from which the adenine is removed is essental for binding of elongation factors, destroying it leaves the ribosome inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, much faster than the cell can replace them, meaning that a single ricin A chain can kill a cell. The B chain binds to complex carbohydrates on the cell surface to facilitate entry of the A Chain into the cell. Without the B chain, the A chain has very low toxicity. Ricin is easily extracted from castor bean (Ricinus comunis), and the lethal dose for humans is very small. It is toxic when inhaled, ingested or injected and there is no known antidote, alhough a vaccine has been developed. Treatment is symptomatic and supportive, with long term organ damage likely in survivors. The ease of extraction and distribution makes it a potential candidate for bilogical warfare although it is less stable than other agents, such as anthrax.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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