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Invitrogen
Rilvegostomig Recombinant Human Monoclonal Antibody
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产品信息
MA5-60159
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Rilvegostomig is a bispecific, humanized immunoglobulin G1 (IgG1) monoclonal antibody designed to block both programmed cell death protein 1 (PD-1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT). Programmed Cell Death Protein 1 (PDCD1), also known as PD-1, is a gene located on chromosome 2q37.3 and encodes a type I transmembrane protein that plays a crucial role in the immune checkpoint pathway. The PD-1 protein comprises an extracellular immunoglobulin variable (IgV)-like domain, a transmembrane region, and an intracellular domain containing immune receptor tyrosine-based inhibitory motifs (ITIMs). PD-1 is an inhibitory receptor expressed on T-cells, B-cells, and myeloid cells and is involved in maintaining peripheral tolerance and preventing autoimmune diseases by downregulating the immune response. On the other hand, T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT), found on chromosome 3q13.31, is also a critical inhibitory receptor that regulates immune response and is primarily expressed on T-cells, regulatory T-cells, and natural killer cells. TIGIT interacts with CD155 on antigen-presenting cells or tumor cells to inhibit T-cell activation and promote immune tolerance, making it a significant target in cancer immunotherapy. Both PD-1 and TIGIT serve as immune checkpoints that modulate the immune response to prevent excessive immune activation and autoimmunity, and they have become key targets for cancer immunotherapy due to their role in downregulating anti-tumor immunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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