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Invitrogen
Rovalpituzumab Humanized Recombinant Human Monoclonal Antibody
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Rovalpituzumab Humanized Antibody (MA5-42077) in SDS-PAGE
SDS-PAGE analysis of Rovalpituzumab Humanized. Samples were run under reducing (R) and non-reducing (NR) conditions using Rovalpituzumab Humanized (Product # MA5-42077) monoclonal antibody. The purity of the protein is greater than 95%.
产品信息
MA5-42077
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human DLL3
偶联物
形式
Liquid
浓度
2.53 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Rovalpituzumab is a biosimilar that targets DLL3. Delta-like protein 3 (DLL3) is a ligand for the Notch signaling pathway. It inhibits primary neurogenesis. DLL3 plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Defects in DLL3 are the cause of Spondylocostal dysostosis autosomal recessive type 1 (SCDO1). Mutations in DLL3 gene cause truncal shortening relative to their limbs, which leads to abdominal protrusion, abnormal spinal curvature and sometimes a plagiocephaly-torticollis sequence. It may be required to divert neurons along a specific differentiation pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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