Immunogen sequence: ALESIYPDSF TVLSENPPSF TITVTSEAGE NDETVQTTLK FTYSEKYPDE APLYEIFSQE NLEDNDVSD
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 100%.
The Formin-like protein 1 (FRL1) gene encodes a formin-related protein which has been implicated in morphogenesis, cyokinesis, and cell polarity. Formins are a conserved class of proteins expressed in all eukaryotes and have one DAD (diaphanous autoregulatory domain), one FH2 (formin homology 2) domain and one GBD/FH3 (Rho GTPase-binding / formin homology 3) domain. FRL1 is located in the cytoplasm and is highly expressed in the spleen, lymph node and bone marrow cells. FRL1 possibly has a role in the control of cell motility, survival of macrophages and cytoskeletal organization.