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Immunogen sequence: KETLAYFIYMV KSNKSRLDQK SEGGKQLE
Highest antigen sequence identity to the following orthologs - mouse 93%, rat 90%.
A novel TGF- beta up-regulated mRNA species, the Sin3-associated protein 30-like, SAP30L has been identified. The predicted nuclear localization signal of SAP30L is sufficient for nuclear transport of the protein although mutating it does not completely remove SAP30L from the nuclei. By reason of its nuclear localization and close homology to SAP30 it is thought that SAP30L might have a role in recruiting the Sin3-histone deacetylase complex to specific co-repressor complexes in response to TGF-beta, leading to the silencing of proliferation-driving genes in the differentiating intestinal epithelial cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DKFZp667L2214; FLJ11526; FLJ23595; FLJ36497; HCV non-structural protein 4A-transactivated protein 2; Histone deacetylase complex subunit SAP30L; SAP30-like; Sin3 corepressor complex subunit SAP30L; Sin3-associated protein p30-like; Sin3A associated protein p30-like
基因别名: NS4ATP2; SAP30L
UniProt ID: (Human) Q9HAJ7
Entrez Gene ID: (Human) 79685
分子生物学功能: chromatin/chromatin-binding, or -regulatory protein