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Invitrogen
SAP97 Polyclonal Antibody
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SAP97 Antibody (PA5-18790) in ICC/IF
Immunofluorescence analysis of DLG1 was performed using neural stem cells (NSC) differentiated into neurons. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with SAP97 Polyclonal Antibody (Product # PA5-18790) at 1:200 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Goat IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product #... View More
产品信息
PA5-18790
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (NSKTRDKGEIPDD) corresponding to the internal amino acids of DLG1 (aa 661-674).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
靶标信息
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; discs, large homolog 1 (Drosophila) transcript variant 6-v1; discs, large homolog 1 (Drosophila) transcript variant 6-v2; Disks large homolog 1; DKFZp761P0818; DKFZp781B0426; hDlg; presynaptic protein SAP97; SAP-97; Synapse-associated protein 97
基因别名: dJ1061C18.1.1; DLG1; DLGH1; hdlg; SAP-97; SAP97
UniProt ID: (Human) Q12959
Entrez Gene ID: (Human) 1739
guanylate kinase activity
phosphoprotein phosphatase activity
protein binding
protein C-terminus binding
cytoskeletal protein binding
ligand-gated ion channel activity
potassium channel regulator activity
protein kinase binding
phosphatase binding
mitogen-activated protein kinase kinase binding
protein complex scaffold
ionotropic glutamate receptor binding
ion channel binding
L27 domain binding
cadherin binding involved in cell-cell adhesion
scaffold/adaptor protein
negative regulation of transcription from RNA polymerase II promoter
branching involved in ureteric bud morphogenesis
immunological synapse formation
endothelial cell proliferation
lens development in camera-type eye
T cell cytokine production
protein dephosphorylation
actin filament organization
mitotic cell cycle checkpoint
establishment or maintenance of cell polarity
chemical synaptic transmission
nervous system development
positive regulation of cell proliferation
regulation of cell shape
viral process
single organismal cell-cell adhesion
peristalsis
positive regulation of actin filament polymerization
cortical actin cytoskeleton organization
astral microtubule organization
membrane raft organization
regulation of myelination
activation of protein kinase activity
ion transmembrane transport
cellular protein complex localization
T cell activation
negative regulation of T cell proliferation
regulation of membrane potential
amyloid precursor protein metabolic process
receptor clustering
positive regulation of potassium ion transport
cortical microtubule organization
establishment or maintenance of epithelial cell apical/basal polarity
negative regulation of mitotic cell cycle
GMP metabolic process
GDP metabolic process
reproductive structure development
embryonic skeletal system morphogenesis
smooth muscle tissue development
negative regulation of epithelial cell proliferation
establishment of centrosome localization
negative regulation of protein kinase B signaling
hard palate development
negative regulation of ERK1 and ERK2 cascade
bicellular tight junction assembly
protein localization to plasma membrane
positive regulation of establishment of protein localization to plasma membrane
receptor localization to synapse
regulation of NIK/NF-kappaB signaling
regulation of sodium ion transmembrane transport
negative regulation of p38MAPK cascade
