Invitrogen

SAPK4 Polyclonal Antibody

产品信息

PA5-50553

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:2,000	-
免疫组化（石蜡） (IHC (P))	1:25-1:100	-

产品规格
种属反应	Human, Mouse, Rat
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthetic peptide corresponding to residues near the C terminal of human mitogen-activated protein kinase 13 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	1.3 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 40% glycerol
内含物	0.05% sodium azide
保存条件	-20°C
RRID	AB_2636006

产品详细信息

The antibody detects endogenous levels of total MAPK13 protein.

靶标信息

p38 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases, or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: MAP kinase 13; MAP kinase p38 delta; MAPK 13; mitogen activated protein kinase 13; Mitogen-activated protein kinase 13; Mitogen-activated protein kinase p38 delta; p38 delta MAP kinase; SAPK/Erk/kinase 4; Stress-activated protein kinase 4

基因别名: MAPK 13; MAPK-13; MAPK13; p38delta; PRKM13; SAPK4; Serk4

UniProt ID: (Human) O15264, (Mouse) Q9Z1B7

Entrez Gene ID: (Human) 5603, (Rat) 29513, (Mouse) 26415

分子生物学功能: non-receptor serine/threonine protein kinase