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Rockland
SARS-CoV-2 Beta Variant Spike Protein Monoclonal Antibody (25D10.E3.F9)
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SARS-CoV-2 Beta Variant Spike Protein Antibody (200-301-MU5) in ELISA
ELISA results of Mouse Anti-SARS CoV-2 Beta B.1.351 Variant Spike Protein Antibody. Each well was coated in duplicate with 10 µg/mL of SARS CoV-2 Beta (B.1.351 variant) [GREEN line], SARS CoV-2 (B.1.1.7 variant) [RED line], SARS CoV-2 (P.1 variant) [BLUE line], SARS CoV-2 (B.1.525 variant) [PURPLE line]. Additional assays were run against peptides representing other SARS CoV-2 variants (B.1.429/CAL.20, B.1.... View More
产品信息
200-301-MU5
产品规格
种属反应
Virus
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
25D10.E3.F9
抗原
This protein A purified antibody was produced by repeated immunizations in mice with a synthetic peptide from an internal region of the SARS-CoV-2 Spike protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.01% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The SARS-CoV-2 Beta Spike Protein S1/S2 refers to the specific regions of the spike (S) protein found in the Beta variant of the SARS-CoV-2 virus, which causes COVID-19. The spike protein is essential for the virus's ability to infect host cells and is composed of two main subunits: S1, which contains the receptor-binding domain (RBD) responsible for attaching to the host cell receptor angiotensin-converting enzyme 2 (ACE2), and S2, which facilitates the fusion of the viral and host cell membranes. The S1/S2 cleavage site is a critical point where host proteases cleave the spike protein, activating it for membrane fusion and viral entry. The Beta variant, first identified in South Africa, has mutations in the spike protein, including at the S1/S2 cleavage site, which may affect the virus's transmissibility and resistance to neutralizing antibodies, impacting vaccine efficacy and treatment strategies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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