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Invitrogen
SARS-CoV-2 NSP5 Recombinant Rabbit Monoclonal Antibody (HL1367)
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SARS-CoV-2 NSP5 Antibody (MA5-47017) in ICC/IF
Immunofluorescent analysis of SARS-CoV-2 NSP5 in mock and transfected 293T cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: SARS-CoV-2 (COVID-19) 3CLpro (nsp5) stained by SARS-CoV-2 (COVID-19) 3CLpro (nsp5) monoclonal antibody (Product # MA5-47017) diluted at 1:500. Blue: Hoechst 33342 staining.
产品信息
MA5-47017
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1367
抗原
Recombinant fragment of SARS-CoV-2 (COVID-19) 3CLpro (nsp5)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
SARS-CoV-2 NSP5 is a non-structural protein in which the main protease targets RIG-I and mitochondrial antiviral signaling (MAVS) protein via two distinct mechanisms for inhibition. NSP5 cleaves off the 10 most-N-terminal amino acids from RIG-I and deprives it of the ability to activate MAVS, whereas NSP5 promotes the ubiquitination and proteosome-mediated degradation of MAVS. NSP5 potently inhibits interferon (IFN) induction by double-stranded RNA (dsRNA) in an enzyme-dependent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: COVID-19 Envelope; SARS-CoV-2; SARS-CoV-2 Envelope
