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Abnova
SASS6 Polyclonal Antibody, MaxPab™
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SASS6 Antibody (H00163786-B01P) in WB
Western Blot analysis of SASS6 expression in transfected 293T cell line (H00163786-T01) by SASS6 MaxPab polyclonal antibody.
Lane 1: SASS6 transfected lysate(53.9 KDa).
Lane 2: Non-transfected lysate.
Lane 1: SASS6 transfected lysate(53.9 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00163786-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SASS6 (AAI01027.1, 1 a.a. approximately 490 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MQSLDDATKQ LDFTRKTLAE KKQELDKLRN EWASHTAALT NKHSQELTNE KEKALQAQVQ YQQQHEQQKK DLEILHQQNI HQLQNRLSEL EVANKDLTER KYKGDSTIRE LKAKLSGVEE ELQRTKQEVL SLRRENSTLD VECHEKEKHV NQLQTKVAVL EQEIKDKDQL VLRTKEAFDT IQEQKVVLEE NGEKNQVQLG KLEATIKSLS AELLKANEII KKLQGDLKTL MGKLKLKNTV TIQQEKLLAE KEEKLQKEQK ELQDVGQSLR IKEQEVCKLQ EQLEATVKKL EESKQLLKNN EKLITWLNKE LNENQLVRKQ DVLGPSTTPP AHSSSNTIRS GISPNLNVVD GRLTYPTCGI GYPVSSAFAF QNTFPHSISA KNTSHPGSGT KVQFNLQFTK PNASLGDVQS GATISMPCST DKENGENVGL ESKYLKKRED SIPLRGLSQN LFSNSDHQRD GTLGALHTSS KPTALPSASS AYFPGQLPNS
靶标信息
Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HsSAS-6; spindle assembly 6 homolog; Spindle assembly abnormal protein 6 homolog; Spindle assembly defective protein 6
基因别名: MCPH14; SAS-6; SAS6; SASS6
UniProt ID: (Human) Q6UVJ0
Entrez Gene ID: (Human) 163786
