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A suggested positive control is mouse brain tissue lysate.
PA5-20532 can be used with blocking peptide PEP-0652.
DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DNA-binding protein SATB2; FLJ21474; FLJ32076; KIAA1034-like DNA binding protein; MGC119474; MGC119477; SATB family member 2; special AT-rich sequence binding protein 2; Special AT-rich sequence-binding protein 2; two cut domains-containing homeodomain protein
基因别名: GLSS; KIAA1034; mKIAA1034; RGD1562369; SATB2
UniProt ID: (Human) Q9UPW6, (Mouse) Q8VI24
Entrez Gene ID: (Human) 23314, (Mouse) 212712, (Rat) 501145