Invitrogen

SCLY Polyclonal Antibody

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SCLY Antibody (PA5-110344) in WB

Western blot analysis of SCLY in extracts of various cell lines. Samples were incubated with SCLY Polyclonal antibody (Product # PA5-110344) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

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产品信息

PA5-110344

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 284-453 of human SCLY (NP_057594.4).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

3.47 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2855755

产品详细信息

Immunogen sequence: FTPLYPMLFG GGQERNFRPG TENTPMIAGL GKAAELVTQN CEAYEAHMRD VRDYLEERLE AEFGQKRIHL NSQFPGTQRL PNTCNFSIRG PRLQGHVVLA QCRVLMASVG AACHSDHGDQ PSPVLLSYGV PFDVARNALR LSVGRSTTRA EVDLVVQDLK QAVAQLEDQA

靶标信息

The SCLY gene encodes selenocysteine lyase, an enzyme involved in selenium metabolism, which plays a critical role in the recycling of selenocysteine from selenoproteins. SCLY catalyzes the conversion of selenocysteine into alanine, releasing selenium for reuse in the biosynthesis of new selenoproteins. It is chiefly active in the liver and kidneys, contributing to maintaining selenium homeostasis, which is vital for numerous biological functions due to selenium's role in antioxidant defense and thyroid hormone metabolism. Alterations in SCLY function or expression can affect selenium levels in the body and are associated with disorders related to oxidative stress and metabolic imbalances. Given the importance of selenium in cellular protection and immune function, SCLY is also of interest in studies focusing on dietary supplementation and disease prevention strategies, particularly in conditions like cancer and cardiovascular diseases where oxidative damage is prevalent.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。