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Invitrogen
SCN2A Polyclonal Antibody
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SCN2A Antibody (PA5-111803) in IHC (F)
Immunohistochemistry analysis of SCN2A in perfusion-fixed, frozen rat paraventricular nucleus tissue sections using SCN2A Antibody (Product # PA5-111803) at a dilution of 1:2000 and a MTNR1B Antibody. A) MTNR1B staining (red) (arrows). B) The same section labeled for NaV1.2 (green). C) Merge of A and B demonstrates partial co-localization of MTNR1B and NaV1.2 in the paraventricular nucleus (PVN). For orient... View More
产品信息
PA5-111803
产品规格
宿主/亚型
Guinea pig
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide corresponding to amino acid residues 467-485 of rat NaV1.2 (Intracellular loop between domains I and II)
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: (C)ASAESRD FSGAGGIGVF SE
Homology: Human amino acid residues are identical.NaV1.3 - 12/15 amino acid residues identical.
靶标信息
Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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