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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:200-1:1,000 | - |
免疫组化（冰冻） (IHC (F)) |
Assay-Dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Peptide (C)KTEEEGKTDGEGNAEDGAK, corresponding to amino acid residues 197-215 of rat beta2 subunit of voltage-gated Na+ channels |
偶联物 |
Unconjugated |
形式 |
Lyophilized |
浓度 |
0.85 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 1% BSA |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2736567 |
Product is shipped at room temperature as a lyophilized powder and should be stored at -20C upon receipt.
Reconstitute using 50 uL deionized water.
Scn2b is a member of voltage-gated sodium channels (NaV) that are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. Scn2b are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Scn2b is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. In Scn2b, the subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Also, Scn2b interacts with TNR (Tenascin R-precursor) and may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. The protein encoded by the Scn2b gene is the beta 2 subunit of the type II voltage-gated sodium channel. Scn2b protein is involved in cell-cell adhesion and cell migration. Defects in the Scn2b gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. Diseases associated with SCN2B include Atrial Fibrillation, Familial, 14 and Scn2b-Related Familial Atrial Fibrillation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: neuronal voltage-gated sodium channel beta 2 subunit; Sodium channel beta 2; Sodium channel subunit beta-2; sodium channel, voltage gated, type II beta subunit; sodium channel, voltage-gated, type II, beta polypeptide
基因别名: 2810451E09Rik; AI840361; ATFB14; Gm183; SCN2B; SCNB2; UNQ326/PRO386
UniProt ID: (Human) O60939, (Rat) P54900, (Mouse) Q56A07
Entrez Gene ID: (Human) 6327, (Rat) 25349, (Mouse) 72821
分子生物学功能:
myelin protein
