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Immunogen sequence: PTNTQWCFDI QWCPRNPAVL SAASFDGRIS VYSIMGGSTD GLRQKQVDKL SSSFGNLDPF GTGQPLPPLQ IPQQTAQHSI VLPLKKPPKW IRRPVGASFS FGGKLVTFEN VRMPSHQGAE QQQQQHHVFI SQVVTEKEFL SRSDQLQQAV QSQGFINYCQ KKIDASQTEF EKNVWSFLKV NFEDDSRGKY LELLGYRKED L; Positive Samples: Mouse liver, Rat liver; Cellular Location: COPII-coated vesicle membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Peripheral membrane protein
The protein encoded by this gene is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII, in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ABP125; ABP130; Protein transport protein Sec31A; SEC31 homolog A, COPII coating complex component; SEC31-like 1; SEC31-like protein 1; SEC31-related protein A; vesicle associated protein; Vesicle-associated protein 1; Web1-like protein; yeast Sec31p homolog
基因别名: 1810024J13Rik; ABP125; ABP130; AU042160; HSPC275; HSPC334; KIAA0905; SEC31A; SEC31L1; VAP1
UniProt ID: (Human) O94979, (Mouse) Q3UPL0, (Rat) Q9Z2Q1
Entrez Gene ID: (Human) 22872, (Mouse) 69162, (Rat) 93646
分子生物学功能:
vesicle coat protein